Plasma endothelin-1 levels depress optic nerve head circulation detected during the glucose tolerance test |
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Authors: | Teruyo Kida Tetsuya Sugiyama Hidehiro Oku Seiyo Harino Tsunehiko Ikeda |
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Institution: | (1) Department of Ophthalmology, Osaka Medical College, Osaka, Japan;(2) Department of Ophthalmology, Yodogawa Christian Hospital, Osaka, Japan;(3) Department of Ophthalmology, University of California, San Diego, 9500 Gilman Drive #0946, La Jolla, CA 92093-0946, USA |
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Abstract: | Purpose To determine the relationship between the changes in optic nerve head (ONH) circulation and the level of plasma endothelin-1
(ET-1) during the glucose tolerance test (GTT).
Methods Twenty-six healthy volunteers with normal GTT and 15 patients with mild hyperglycemia and abnormal GTT were studied. The ONH
circulation square blur rate (SBR) value], blood pressure, intraocular pressure (IOP), blood glucose, blood insulin and plasma
ET-1 were determined before and every hour up to 3 h after an oral intake of 75 g of glucose.
Results The SBR increased in the normal glucose tolerance group at all times during the GTT, but it decreased significantly in the
abnormal glucose tolerance group (P < 0.05). Before the GTT, the plasma ET-1 level was not significantly different in the two groups; however, the level increased
1 h after the oral GTT in the abnormal glucose tolerance group (P < 0.05). No significant changes were observed in mean blood pressure or IOP.
Conclusions ONH circulation increased after glucose intake in the normal glucose tolerance group and remained high even after the blood
glucose level had returned to its baseline. The decrease in ONH circulation in the abnormal glucose tolerance group was attributed
partly to the increased ET-1. |
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Keywords: | Endothelin-1 Glucose tolerance test Laser speckle method Optic nerve head circulation |
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