L-histidine inhibits production of lysophosphatidic acid by the tumor-associated cytokine,autotaxin期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

L-histidine inhibits production of lysophosphatidic acid by the tumor-associated cytokine,autotaxin

Authors:	Timothy?Clair author-information" > author-information__contact u-icon-before" > mailto:timclair@helix.nih.gov" title=" timclair@helix.nih.gov" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author,Eunjin?Koh,Malgorzata?Ptaszynska,Russell?W?Bandle,Lance?A?Liotta,Elliott?Schiffmann,Mary?L?Stracke

Affiliation:	(1) Laboratory of Pathology, National Cancer Institute, National Institutes of Health, 20892 Bethesda, Maryland, USA

Abstract:	Background Autotaxin (ATX, NPP-2), originally purified as a potent tumor cell motility factor, is now known to be the long-sought plasma lysophospholipase D (LPLD). The integrity of the enzymatic active site, including three crucial histidine moieties, is required for motility stimulation, as well as LPLD and 5'nucleotide phosphodiesterase (PDE) activities. Except for relatively non-specific chelation agents, there are no known inhibitors of the ATX LPLD activity.

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