The effect of pulsed holmium-YAG laser on in vitro and in vivo atherosclerotic plaque |
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Authors: | Jairo Kusniec Mickey Scheinowitz Michael Eldar Prof Alexander Battler |
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Institution: | (1) Neufeld Cardiac Research Institute, Tel Aviv University, Sheba Medical Centre, 5261 Tel Hashomer, Israel |
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Abstract: | Laser application for atherosclerotic ablation is still limited. The pulsed Holmium-YAG (HO-YAG) laser has physical characteristics
which may improve vascular recanalization. We therefore examined the effect of this laser on cadaver human atherosclerotic
aortae, human amputated legs and atherosclerotic rabbits in vivo. The pulsed HO-YAG laser successfully ablated calcific and
fibrotic aortic segments. Totally occluded arteries in amputated legs including calcified atherosclerotic lesions were successfully
recanalized using 165–350 pulses of 0.35–0.4 J energy per pulse transmitted through commercially available fibre optics. Percutaneous
delivery of laser energy to the descending aorta of atherosclerotic rabbits was not traumatic to the arterial wall. These
results demonstrate the advantages of the pulsed HO-YAG laser to ablate fibrotic and calcific atheroma and to safely recanalize
occluded arteries. |
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Keywords: | Laser angioplasty Holmium-YAG Atherosclerosis |
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