| 异位性皮炎超微病理、免疫病理改变及临床意义 |
| |
| 引用本文： | 张玉环,沈伟,纪华安,谢艳秋,张理涛. 异位性皮炎超微病理、免疫病理改变及临床意义[J]. 中国中西医结合皮肤性病学杂志, 2003, 2(3): 158-161 |
| |
| 作者姓名： | 张玉环 沈伟 纪华安 谢艳秋 张理涛 |
| |
| 作者单位： | 1. 天津市长征医院变态反应科,天津,300021
2. 天津医科大学电镜室,天津,300010 |
| |
| 基金项目： | 天津市卫生局科技处资金资助课题(2000,00KYZDI) |
| |
| 摘 要： | 目的 通过探讨异位性皮炎(AD)皮损超微病理结构和免疫球蛋白在皮损中的沉积种类，为临床治疗提供理论依据。方法 对10例AD患者皮损进行了常规病理、电镜和免疫病理的观察。结果 AD皮损常规病理表现为皮肤的亚急性和慢性炎症改变；电镜下存在免疫反应细胞相互接触现象；免疫球蛋白亚类的沉积以IgG1为主，沉积部位主要为真皮乳头区域。结论 细胞间的相互接触现象可能为皮肤免疫应答反应的细胞形态学基础，而皮损中IgG1的沉积可能与皮肤的感染有关。
|
| 关 键 词： | 异位性皮炎 超微病理 免疫病理 AD 免疫细胞 |
| 文章编号： | 1672-0709(2003)03-0158-04 |
| 修稿时间： | 2003-05-14 |
Ultrastructural and Immunopathological Manifestation of Atopic Dermatitis and Its Significance in Clinic |
| |
| ZHANG Yu-huan ,SHEN Wei ,JI Hua-an ,XIE Yan-qiu,ZHANG Li-tao. Ultrastructural and Immunopathological Manifestation of Atopic Dermatitis and Its Significance in Clinic[J]. Chinese J of Dermatovenerology Integr Tradit and West Med, 2003, 2(3): 158-161 |
| |
| Authors: | ZHANG Yu-huan SHEN Wei JI Hua-an XIE Yan-qiu ZHANG Li-tao |
| |
| Affiliation: | ZHANG Yu-huan 1,SHEN Wei 2,JI Hua-an 1,XIE Yan-qiu,ZHANG Li-tao 1 1.Department of Allergology,Changzheng Hospital,Tianjin300021,China,2.Department of Electro-microscope,Tianjin Medical University,Tianjin300010,China |
| |
| Abstract: | Objectives To observe the ultrastructural pathology and immno-pathology in biopsy from of atopic der-matitis(AD).Methods Pathology under microscope,electroscope,as well as immuno-fluorescence was carried out in lesions of10AD patients.Results Under microscope in pathology,there are mainly sub-acute or chronic changes in AD.And the mutual contacting of immunoreactive cells are observed under electroscope.By immuno-fluorescence,the main subtype of immunolobulin precipitation is IgG 1 ,which is prevalence in papilla dermis.Conclusion The mutual contact-ing phenomenon of immuno-cells might be the morphological basis of cellular immunoreaction.And,IgG 1 precipitation in lesion and dermis implicated that there be correlation between AD and epidermal infection. |
| |
| Keywords: | atopic dermatitis ultrastructural pathology immuno-pathology |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
