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Secondary Metabolites of Endophytic Fungus Aspergillus TQ67 from Suaeda glauca

??OBJECTIVE To study the secondary metabolites of endophytic fungus Aspergillus TQ67 isolated from Suaeda glauca. METHODS The compounds were isolated and purified by ODS reversed-phase column, preparative HPLC and HPLC techniques.And their structures were identified by the physicochemical properties and spectral analysis. RESULTS The compounds were identified as aspermutarubrol (1), sydowiols D (2), sydowiol E (3), L-tenuazonic acid (4), (E)-5-(hydroxymethyl)-2-(6′-methylhept-2′-en-2′-yl)phenol (5), sydonol (6), (7S)-(+)-7-O-methylsydonol (7), and hydroxysydonic acid (8). Compounds 2/3 and compound 1 were different from other compounds with IC₅₀ values of (9.79±0.33) and (32.30±1.02) μg·mL^-1 by DPPH assay and (230.55±2.50) and (278.99±8.32) μg·mL^-1 by FRAP assay, respectively. CONCLUSION Compounds 2/3 and compound 1 isolated from endophytic fungus Aspergillus TQ67 isolated from Suaeda glauca show strong antioxidant activity.