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引用本文:??????,???÷,???,?ξ???,?????,?????.???????????????о?[J].中国药学杂志,2018,53(15):1265-1272.
作者姓名:??????  ???÷  ???  ?ξ???  ?????  ?????
作者单位:??????????,?? ??? 523808;
摘    要:

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Chemical Constituents from the Root Bark of Celastrus monospermus
CHEN Ming-xiang,YANG Xue-mei,GUAN Rui,SONG Jing-jing,HU Ai-di,ZHENG Ming-bin.Chemical Constituents from the Root Bark of Celastrus monospermus[J].Chinese Pharmaceutical Journal,2018,53(15):1265-1272.
Authors:CHEN Ming-xiang  YANG Xue-mei  GUAN Rui  SONG Jing-jing  HU Ai-di  ZHENG Ming-bin
Institution:School of Pharmacy, Guangdong Medical University, Dongguan 523808, China;
Abstract:??OBJECTIVE To study the chemical constituents from the root bark of Celastrus monospermus Roxb. METHODS The compounds were isolate and purified by repeated column chromatography on silica gel, ODS and Sephadex LH-20, and the chemical structures of compounds were determined by spectral data analyses. RESULTS Twenty-three compounds were isolated from this plant, which were identified as ??-sitosterol palmitate (1), friedelan-3-one (2), 3??-hydroxyolean-12-en (3), 3??-hydroxylcholest-5,22-dien (4), ??-sitosterol (5), 3,22-dioxo-20-taraxastene (6), 3,12-dioxofriedelane (7), 3-oxo-28-hydroxyfriedelane (8), 3-oxo-11??-hydroxyfriedelane (9), 3-oxo-12??-hydroxyfriedelane (10), pristimerin(11), 3-oxo-30-hydroxyfriedelane (12), 3-oxo-29-friedelanoic acid (13), salaspermic acid (14), celastrol (15), 3??, 21??-dihydroxy-30-nor-friedelan-20(29)-en-27-oic acid (16), 3??, 22??-dihydroxy-olean-12-en-29-oic acid (17), wilforol A (18), orthosphenic acid (19), p-hydroxybenzoic acid (20), 3-oxo-2??-hydroxyfriedelan-29-oic acid (21), 21-oxo-2??,3??,22??-trihydroxy-29-nor-friedelan-24,2??-lactone (22)and daucosterol (23). CONCLUSION Compounds 1,6, 13-14,16-22 are obtained from this plant for the first time, and compounds 16, 20-22 are isolated from the genus Celastrus for the first time.
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