胶质母细胞瘤术后调强放疗靶区勾画进展

胶质母细胞瘤的标准治疗方案包括手术切除,术后放疗,并同期辅以替莫唑胺口服化疗。放疗与否同患者的生存时间直接相关,但放疗的靶区勾画标准仍存在极大争议。本文首先分析了国内外对临床靶区外放范围的不同观点,总结胶母细胞瘤放疗后的复发模式。其次,阐述了目前无法精确勾画外放边界的技术原因,并且我们认为参考患者的临床和病理特征来勾画一个个体化的放疗靶区非常重要。最后,本文探讨了放疗在胶母细胞瘤中的应用前景,旨在勾画更为精确的放疗靶区使患者最大获益。

The progress on the delineation of target volume in postoperative intensity-modulated radiotherapy for glioblastoma

The standard treatments of glioblastoma include surgery, postoperative radiotherapy and concurrent and adjuvant temozolomide-based chemotherapy. Radiotherapy is directly related to the overall survival rate. Nevertheless, the standard delineation of target volume during radiotherapy remains controversial. In this article, different standpoints upon the range of delineation of tumor volume were analyzed and the recurrence pattern of glioblastoma after radiotherapy was summarized. Besides, the technical causes of the failure to accurately delineate the tumor outline were identified. It is of significance to deliver individualized delineation of target volume by referring to the clinical and pathological characteristics of each patient. Finally, the application prospect of radiotherapy in the treatment of glioblastoma was discussed in this article, aiming to enhance the accuracy of target volume delineation during radiotherapy and maximize the clinical benefits to the patients.