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Protective Effect of Glycyrrhetinic Acid on Myocardial Ischemia/Reperfusion Injury

??OBJECTIVE To explore the protective effect of glycyrrhetinic acid (GA) on myocardial ischemia/reperfusion injury. METHODS Forty-eight healthy male SD rats were randomly and averagely divided into six groups: sham, control, and control with tanshinone ??A sodium injection, GA at low, median and high dosages. The rats were subjected to 30 min of ischemia, followed by 180 min reperfusion. The influence of GA on arrhythmic during reperfusion period was observed. At the end of reperfusion period, the concentrations of CK-MB and LDH in serum were measured with assay kits, and the myocardial infarct size was measured with colouring method. RESULTS At the time of myocardial ischemia and reperfusion, the HR, MAP and PRI in any GA group were not significantly different compared with the control group. At the end of the reperfusion period, the myocardial infarct sizes were decreased significantly in median and high dosage GA groups compared with the control group (P<0.05); the CK-MB concentration in serum in all the GA groups were much lower (P<0.05); the LDH concentrations in serum were much lower in median and high dosage GA groups (P<0.05). CONCLUSION GA exerts protection against myocardial ischemia/reperfusion as shown by a significant reduction in infarct size and decreased concentrations of CK-MB and LDH in serum.