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Effects of p-Coumaric Acid on Preventing Acute Hypoxia-Induced Pulmonary Edema Mice

??OBJECTIVE To study the preventing effects of p-coumaric acid(p-CA) on acute hypoxia-induced pulmonary edema by mice experiments. METHODS Acute-hypoxia model was established using a normobaric hypoxia chamber in vivo. Salidroside was set as a positive control drug. And the test period was 7 d using a method of intragastric administration. The measurements including pulmonary water content, HE staining, inflammatory factors, anti-oxidative indexes and Na⁺, K⁺-ATPase were performed to determine the efficacies and mechanisms of p-CA on preventive against acute hypoxia-induced pulmonary edema. RESULTS As compared with the normal group, pulmonary water contents increased significantly by 3.56% in the mice treated with acute hypoxia (9.5% O₂) for 6 h (control group) (P<0.01), and administration with p-CA (25, 100 mg??kg^-1??d^-1) for 7 d could significantly reduce this index (P<0.05), which was as effective as the positive group. The action mechanisms of p-CA could be due to its abilities of improving the activity of Na⁺, K⁺-ATPase, enhancing antioxidant capacity (SOD??, CAT?? and MDA??) and inhibiting inflammatory factors (IL-1?? and IL-6). CONCLUSION p-CA has greater preventive effects on acute hypoxia-induced pulmonary edema in mice.