| 放疗联合免疫检查点抑制剂治疗肿瘤的应用基础 |
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| 引用本文： | 惠周光,袁梦,门玉.放疗联合免疫检查点抑制剂治疗肿瘤的应用基础[J].中华放射肿瘤学杂志,2018,27(10):875-879. |
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| 作者姓名： | 惠周光 袁梦 门玉 |
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| 作者单位： | 100021 北京,国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院特需医疗部(惠周光、门玉),放疗科(袁梦) |
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| 基金项目： | 国家重点研发计划项目(2017YFC1311000、2016YFC0904600);首都临床特色应用研究(Z171100001017114);中国医学科学院医学与健康科技创新工程项目(重大协同创新项目2016-I2M-1-011);北京希望马拉松专项基金联合攻关课题(LC2016L03) |
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| 摘 要： | 免疫检查点抑制剂单药有效率不足30%。放疗可以促进机体的抗肿瘤免疫应答,通过协同效应或互补机制增进免疫检查点抑制剂的疗效。笔者就放疗联合免疫检查点治疗的应用基础及面临的问题进行深入阐述。
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| 关 键 词： | 肿瘤/放射疗法 肿瘤/免疫疗法 免疫检查点抑制剂 远隔效应 |
| 收稿时间： | 2018-03-06 |
Application mechanisms of radiotherapy combined with immune checkpoint inhibitors |
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| Hui Zhouguang,Yuan Meng,Men Yu.Application mechanisms of radiotherapy combined with immune checkpoint inhibitors[J].Chinese Journal of Radiation Oncology,2018,27(10):875-879. |
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| Authors: | Hui Zhouguang Yuan Meng Men Yu |
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| Institution: | Department of VIP Medical Services (Men Y,Hui ZG), Department of Radiation Oncology (Yuan M),National Cancer Center/ National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China |
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| Abstract: | Remarkable advances have been made in immunotherapy, especially immune checkpoint inhibitors. However, only less than 30% patients would respond to single checkpoint inhibitors. Radiotherapy can augment the anti-tumor immune responses elicited by immunotherapy, either by way of synergy or complementation. This article reviews the mechanisms, the advances and challenges in combination therapy. |
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| Keywords: | Neoplasms/radiotherapy Neoplasms/immunotherapy Immune checkpoint inhibitor Abscopal effect |
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