| 局部晚期非小细胞肺癌放疗剂量提升研究进展 |
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| 引用本文： | 王大权,毕楠,王绿化. 局部晚期非小细胞肺癌放疗剂量提升研究进展[J]. 中华放射肿瘤学杂志, 2019, 28(10): 788-791. DOI: 10.3760/cma.j.issn.1004-4221.2019.10.016 |
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| 作者姓名： | 王大权 毕楠 王绿化 |
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| 作者单位： | 国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院放疗科 100021 |
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| 摘 要： | 局部晚期非小细胞肺癌的RTOG0617研究显示进一步提高放疗剂量并没有带来生存获益,这促进了剂量提升策略的改变。目前多项研究通18FDG高摄取区域局部加量、同步加量调强放疗、改变剂量分割模式等探索更为有效的剂量提升手段,并取得一系列进展。PET-CT技术及调强放疗技术的广泛应用,为放疗剂量优化和提升提供了广阔空间。
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| 关 键 词： | 肺肿瘤/放射疗法 剂量提升 同步加量 |
| 收稿时间： | 2018-05-20 |
Research progress on radiation dose escalation for locally advanced non-small cell lung cancer |
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| Wang Daquan,Bi Nan,Wang Lvhua. Research progress on radiation dose escalation for locally advanced non-small cell lung cancer[J]. Chinese Journal of Radiation Oncology, 2019, 28(10): 788-791. DOI: 10.3760/cma.j.issn.1004-4221.2019.10.016 |
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| Authors: | Wang Daquan Bi Nan Wang Lvhua |
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| Affiliation: | Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing 100021,China |
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| Abstract: | RTOG0617 trial has indicated that no benefit can be obtained in the overall survival of locally advanced non-small cell lung cancer patients by improving the prescribed dose, which promotes the adjustments to the strategies of dose escalation. Currently, multiple studies have been designed to explore more effective approaches to boost dose, such as dose boosts based on increased 18FDG-uptake regions, simultaneous integrated boost intensity-modulated radiotherapy and modulation of dose fractions, which have achieved a series of progress. The widespread application of PET-CT and intensity-modulated radiotherapy offers broad space for the dose escalation and optimization. |
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| Keywords: | Lung neoplasm/radiotherapy Dose escalation Simultaneous integrated boost |
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