| 五磨饮对脾虚气滞证功能性消化不良大鼠脑肠肽的影响 |
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| 引用本文： | 吴晓芳, 甘国兴, 冯伟勋, 邝卫红, 李劲平, 谢保平, 张国民. 五磨饮对脾虚气滞证功能性消化不良大鼠脑肠肽的影响[J]. 中国现代应用药学, 2020, 37(7): 814-820. DOI: 10.13748/j.cnki.issn1007-7693.2020.07.008 |
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| 作者姓名： | 吴晓芳 甘国兴 冯伟勋 邝卫红 李劲平 谢保平 张国民 |
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| 作者单位： | 清远职业技术学院, 广东 清远 511510;清远市中医院, 广东 清远 511500;广州中医药大学, 广州 510006;中南大学, 长沙 410013;赣南医学院, 江西 赣州 341000;湖南中医药大学, 长沙 410028 |
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| 基金项目： | 广东省科技发展专项资金（基础与应用基础研究方向）项目（2016A030307032） |
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| 摘 要： | 目的 研究五磨饮对脾虚气滞证功能性消化不良（functional dyspepsia，FD）大鼠脑肠肽的影响，探讨其作用机制。方法 除正常组外，其余大鼠采用
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| 关 键 词： | 功能性消化不良 五磨饮 脑肠肽 |
| 收稿时间： | 2019-03-12 |
Effect of Wumoyin Decoction on Regulating Brain-gut Peptide in Functional Dyspepsia Rats with Spleen Deficiency and Qi Stagnation Syndrome |
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| WU Xiaofang, GAN Guoxing, FENG Weixun, KUANG Weihong, LI Jingping, XIE Baoping, ZHANG Guomin. Effect of Wumoyin Decoction on Regulating Brain-gut Peptide in Functional Dyspepsia Rats with Spleen Deficiency and Qi Stagnation Syndrome[J]. Chinese Journal of Modern Applied Pharmacy, 2020, 37(7): 814-820. DOI: 10.13748/j.cnki.issn1007-7693.2020.07.008 |
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| Authors: | WU Xiaofang GAN Guoxing FENG Weixun KUANG Weihong LI Jingping XIE Baoping ZHANG Guomin |
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| Affiliation: | Qingyuan Polytechnic, Qingyuan 511510, China;Qingyuan Hospital of TCM, Qingyuan 511500, China;Guangzhou University of Chinese Medicine, Guangzhou 510006, China;Central South University, Changsha 410013, China;Gannan Medical University, Ganzhou 341000, China; Hunan University of Traditional Chinese Medicine, Changsha 410028, China |
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| Abstract: | OBJECTIVE To study the effect of Wumoyin decoction on regulating functional dyspepsia rats with spleen deficiency and qi stagnation syndrome, explore its mechanism of action. METHODS Except the normal group, the other rats were modeled by "chronic restraint+swimming+irregular eating" compound factor method. The rats were randomly divided into model group, domperidone group, Chaishao Liujunzi decoction group, Wumoyin decoction high dose group(6.2 g·kg-1), middle dose group(3.1 g·kg-1) and low dose group(1.55 g·kg-1). Besides the normal group and model group, the other groups of rats were given the corresponding drug intervention for 14 d. The content of Ghrelin, MTL, GAS, CCK, VIP, CGRP in plasma were detected by ELISA method, and the expression of Ghrelin, MTL, GAS, CCK, VIP, CGRP in gastric antrum tissue and hypothalamus were detected by immunohistochemistry method. RESULTS Compared with the model group, the Ghrelin and MTL in plasma of rats in Wumoyin decoction each dose group was significantly raised(P<0.01), and the CCK was very significantly reduced(P<0.01). The VIP in plasma of rats in the high dose and middle dose groups were significantly reduced(P<0.05). The CGRP in plasma of rats in the high dose group was significantly reduced(P<0.05). There was no significant difference in the expression of Ghrelin, MTL, GAS, CCK, VIP and CGRP in gastric antrum of rats in each dose group. The expression of Ghrelin in the hypothalamus of the rats in the high dose group was significantly increased(P<0.01). The expressions of Ghrelin, MTL, GAS, VIP, CGRP in the hypothalamus of rats in the middle dose group were significantly increased(P<0.01). CONCLUSION Wumoyin decoction has the effect of regulating the expression of brain gut peptide in rats with functional dyspepsia of spleen deficiency and qi stagnation syndrome, which may be one of its mechanisms. |
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| Keywords: | functional dyspepsia Wumoyin decoction brain-gut peptide |
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