| 非小细胞肺癌脑转移放疗研究进展 |
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| 引用本文： | 吕进财,刘百龙,全晓月,刘敏,董丽华. 非小细胞肺癌脑转移放疗研究进展[J]. 中华放射肿瘤学杂志, 2019, 28(1): 61-64. DOI: 10.3760/cma.j.issn.1004-4221.2019.01.013 |
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| 作者姓名： | 吕进财 刘百龙 全晓月 刘敏 董丽华 |
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| 作者单位： | 吉林大学第一医院放疗科,长春 130021; |
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| 基金项目： | 吉林省发改委(2016C053-1);吉林省科技厅(201603040YY);国家自然科学基金委(81773353, 81602659) |
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| 摘 要： | 自20世纪50年代全脑放疗首次应用于脑转移以来,一直被视为非小细胞肺癌脑转移的标准治疗方案。近年来,随着放疗技术越来越精准、全身治疗方案越来越有效,特别是分子靶向药物以目不暇接的速度更新换代,其靶向性更强、中枢神经系统渗透性更好,患者生存期延长,WBRT的神经系统远期损伤引起广泛关注。本文将对现代综合治疗模式下的非小细胞肺癌脑转移,全脑放疗的相关争议及进展进行综述。
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| 关 键 词： | 肺肿瘤/放射疗法 肿瘤转移 脑 研究进展 |
| 收稿时间： | 2017-12-11 |
Research progress in radiotherapy for brain metastases of non-small cell lung cancer |
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| Lv Jincai,Liu Bailong,Quan Xiaoyue,Liu Min,Dong Lihua. Research progress in radiotherapy for brain metastases of non-small cell lung cancer[J]. Chinese Journal of Radiation Oncology, 2019, 28(1): 61-64. DOI: 10.3760/cma.j.issn.1004-4221.2019.01.013 |
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| Authors: | Lv Jincai Liu Bailong Quan Xiaoyue Liu Min Dong Lihua |
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| Affiliation: | Department of Radiation Oncology,TheFirst Hospital,Jilin University,Changchun 130021,China; |
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| Abstract: | Since the first application of whole brain radiation therapy (WBRT) to brain metastases in 1950 s,it has been regarded as a standard treatment for brain metastases of non-small cell lung cancer (NSCLC).Recently, more accurate radiotherapy technique and more effective systemic therapy have been developed. Especially, the molecular targeted drugs are upgraded rapidly with stronger targeting capability and better permeability of the central nervous system. With the prolonged survival of patients, long-term damage to the nervous system induced by WBRT causes widespread concerns. This article will review the related controversies and research progress in the application of WBRT to NSCLC with brain metastases in modern integrated therapy. |
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| Keywords: | Lung neoplasms/radiotherapy Tumor metastases brain Research progress |
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