Flash放疗

Flash放疗是利用超高剂量率超快辐射所产生的对正常组织有保护作用的Flash效应进行的放疗。由于其独特的放射生物学优势,Flash放疗正受到学术界和工业界越来越多的关注,成为了当前放疗领域的前沿热点。本文总结了目前已开展及计划开展Flash照射实验报道,对各类细胞和动物实验、实验条件及实验结果等进行了归纳;同时介绍了Flash效应可能的生物学机理和分析了Flash放疗面临的挑战,对潜在的临床应用进行了展望。

Flash radiotherapy

Flash radiotherapy (Flash-RT) is a treatment modality that uses the normal tissue sparing regimen induced by ultra-high dose rate and ultra-fast irradiation. Compared to conventional dose rate radiotherapy,Flash-RT has the potential to provide the isoefficacy for tumors while achieving the remarkable normal tissue protection. Due to this unique feature,Flash-RT is attracting more and more attention from the radiotherapy community. An abundance of groups from both academia and industry are extensively studying the therapeutic ratio and underlying biological mechanisms. Here,we review the prior knowledge about Flash-RT and summarize the results that have been reported from various groups using both in vitro and animal studies with different experimental protocols. We also discuss possible biological mechanisms and the challenging of implementing Flash-RT,as well as its possible options for clinical applications.