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Adsorption Property of Avilamycin on Silica Gel-based Absorbent

??OBJECTIVE To investigate the kinetic and thermodynamic characteristics of adsorption of avilamycin on silica gel. METHODS By measuring the adsorption of avilamycin on silica gel at different temperatures, the adsorption kinetics curves and adsorption isotherm were drawn, and the kinetics and thermodynamic parameters were studied. RESULTS The adsorption of avilamycin on silica gel could be described well by Pseudo-second-order model. The adsorption process had feature of shrinking nonreactive core model, and the internal diffusion was the main rate-limiting step. The equilibrium adsorption data of avilamycin on silica gel fit the Langmuir isotherms well. The thermodynamic parameters were as follows:change in entropy (??S) was 108.115 2 J??mol^-1??K^-1, change in enthalpy (??H) was 24.654 6 J??mol^-1, and changes in free energy (??G) were -8.752 9, -8.104 3, and -7.455 6 J??mol^-1 at 309, 303 and 297 K, respectively. CONCLUSION The results of this study provide a theoretical basis for further study on the isolation and purification of high purity avilamycin by silica gel.