| ALK重排非小细胞肺癌脑转移放疗的研究进展 |
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| 引用本文： | 王文惠,孙鑫,惠周光. ALK重排非小细胞肺癌脑转移放疗的研究进展[J]. 中华放射肿瘤学杂志, 2019, 28(6): 467-471. DOI: 10.3760/cma.j.issn.1004.4221.2019.06.016 |
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| 作者姓名： | 王文惠 孙鑫 惠周光 |
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| 作者单位： | 中国医学科学院北京协和医院放疗科 100730;国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院放疗科 100021 |
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| 基金项目： | 国家重点研发计划项目(2017YFC1311000);首都临床特色应用研究(Z171100001017114);中国医学科学院医学与健康科技创新工程项目(重大协同创新项目2016-I2M-1-011);北京希望马拉松专项基金联合攻关课题(LC2016L03) |
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| 摘 要： | 有驱动基因突变的非小细胞肺癌脑转移较为常见,脑部放疗联合靶向药物治疗是目前研究的热点。ALK基因重排是非小细胞肺癌常见的驱动基因突变,但目前有关ALK基因重排非小细胞肺癌脑转移治疗的相关研究还较少,其预后、脑部放疗作用及放疗与ALK抑制剂有效结合值得大家探索。
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| 关 键 词： | ALK基因重排 肺肿瘤 脑转移/放射疗法 肺肿瘤 脑转移/靶向疗法 进展 |
| 收稿时间： | 2018-03-21 |
Research progress on radiotherapy for brain metastasis from non-small-cell lung cancer with ALK rearrangement |
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| Wang Wenhui,Sun Xin,Hui Zhouguang. Research progress on radiotherapy for brain metastasis from non-small-cell lung cancer with ALK rearrangement[J]. Chinese Journal of Radiation Oncology, 2019, 28(6): 467-471. DOI: 10.3760/cma.j.issn.1004.4221.2019.06.016 |
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| Authors: | Wang Wenhui Sun Xin Hui Zhouguang |
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| Affiliation: | Department of Radiation Oncology,Peking Union Medical College Hospital,Chinese Academic of Medical Sciences,Beijing 100730,China;Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC),Beijing 100021,China |
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| Abstract: | Brain metastasis is common in non-small-cell lung cancer (NSCLC) with driver gene mutations. At present, brain radiotherapy combined with tyrosine kinase inhibitor (TKI) is a hot topic. Anaplastic lymphoma kinase (ALK) gene rearrangement is one of the common driver mutations in NSCLC.However, the treatment of brain metastasis from NSCLC with ALK gene rearrangement has been rarely investigated. The prognosis of these patients,the role of brain radiotherapy and the proper combination of radiotherapy with ALK-TKI are worthy of further exploration. |
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| Keywords: | Anaplastic lymphoma kinase gene rearrangement Lung neoplasm brain metastasis/radiotherapy Lung neoplasm brain metastasis/target therapy Progress |
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