正常老年人计算任务的脑功能磁共振成像研究

目的：探讨正常老年人进行脑功能磁共振成像(fMRl)实验的可行性及计算任务的激活脑区。方法：对11例正常老年志愿者进行简单计算任务和复杂计算任务的fMRI实验，以SPM99作后处理显示激活脑区。结果：11例被试的简单计算任务均完成较好，激活区域主要集中在双侧顶上、下小叶和双侧枕叶，复杂计算任务除了以上脑区的激活外，还包括Brdmann9、10区和Brdmann 46区。结论：老年人进行fMRI实验具有可行性，复杂计算任务比简单计算任务激活更多的额叶脑区。

The fMRI study of the calculation tasks in normal aged volunteers

Objective: To investigate the feasibility and cortex activation of fMRI in aged volunteers during the performance of calculation tasks. Methods: Internal mental calculation tasks including simple tasks and complicated tasks were conducted in 11 normal aged volunteers. The fMRI data was postprocessed using SPM99 to reveal the activated cortex. Results: The simple calculation tasks were fulfilled satisfactorily in all aged subjects. Cortex in the bilateral Superior parietal lobule, inferior parietal lobule and bilateral occipital lobes showed activation. We found a selective enhancement of fMRI signal in Brodmann regions 9, 10 and 46 in the complicated tasks. Conclusion: fMRI tasks are feasible in aged people and more cortex of the left frontal lobe shows activation in complicated calculation tasks.