| circRNA作为ceRNA在结直肠癌中的研究进展 |
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| 引用本文： | 刘燕,刘文,汤国辉. circRNA作为ceRNA在结直肠癌中的研究进展[J]. 南华大学学报(医学版), 2023, 0(3): 462-465 |
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| 作者姓名： | 刘燕 刘文 汤国辉 |
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| 作者单位： | 南华大学衡阳医学院附属南华医院 肛肠外科,湖南衡阳 421002;南华大学衡阳医学院附属南华医院 厦门大学药学院,福建厦门 361102 |
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| 基金项目： | 2021年湖南省自然科学基金面上项目(2021JJ30627);2022年湖南省研究生科研创新项目(CX20221021) |
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| 摘 要： | 环状RNA(circRNA)是由前体mRNA反向剪接而产生的共价闭合RNA分子,在疾病中发挥着重要的调控作用。circRNA有潜力成为新型生物标志物,在肿瘤早期诊断、治疗和预后方面发挥重要作用。circRNA可以作为竞争性内源RNA(ceRNA),通过与miRNA相互作用,进而参与基因的转录后调控。本文重点概述了circRNA作为ceRNA调控结直肠癌发生发展的机制,以求能为结直肠癌的诊断与治疗拓展新视野。
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| 关 键 词： | 结直肠癌 环状RNA ceRNA [ |
| 收稿时间： | 2022-08-12 |
| 修稿时间： | 2023-04-22 |
Research progress of circRNA as ceRNA in colorectal cancer |
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| LIU Yan,LIU Wen,TANG Guohui. Research progress of circRNA as ceRNA in colorectal cancer[J]. Journal of Nanhua University(Medical Edition), 2023, 0(3): 462-465 |
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| Authors: | LIU Yan LIU Wen TANG Guohui |
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| Affiliation: | Department of Anorectal Surgery, Affiliated Nanhua Hospital, Hengyang Medical College, University of South China, Hengyang 421002, Hunan, China;School of Pharmaceutical Sciences, Xiamen University, Xiamen 361102, Fujian, China |
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| Abstract: | Circular RNA (circRNA) are covalently closed RNA molecules produced by pre-mRNA back-splicing, which palys an crucial regulatory role in human diseases. circRNA have the potential to become novel biomarkers that play an important role in the early diagnosis, treatment and prognosis of tumors. circRNA can interact with miRNA as competitive endogenous RNA (ceRNA) to participate in the post-transcriptional regulation of genes. This review focuses on the mechanism of circRNA as ceRNA regulating the occurrence and development of colorectal cancer, in order to expand a new vision for the diagnosis and treatment of colorectal cancer. |
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| Keywords: | colorectal cancer circular RNA ceRNA |
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