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Sleep & metabolism: The multitasking ability of lateral hypothalamic inhibitory circuitries
Institution:1. Department of Neurology and Department of Clinical Research, Inselspital University Hospital, University of Bern, Bern, Switzerland;2. Leibniz Institute for Molecular Pharmacology (FMP)/NeuroCure Cluster of Excellence, Berlin, Germany;3. The Francis Crick Institute, Mill Hill Laboratory, London NW7 1AA, UK;4. Department of Developmental Neurobiology, King’s College London, London WC2R 2LS, UK;5. Department of Psychiatry, McGill University, Montreal, QC, Canada;1. Department of Cognitive Neurology, HIH for Clinical Brain Research, Otfried-Müller-Str. 27, 72076 Tübingen, Germany;2. Department of Integrative Medical Biology, Umeå University, Linnéus väg 9, 901 87 Umeå, Sweden;1. CRNL, SLEEP Team, UMR 5292 CNRS/U1028 INSERM, Université Claude Bernard Lyon 1, Lyon, F-69372, France;2. Avian Sleep Group, Max Planck Institute for Ornithology, Eberhard-Gwinner-Strasse 5, 82319 Seewiesen, Germany;1. INSERM, U1028, CNRS, UMR5292, Lyon Neuroscience Research Center, Team “Physiopathologie des réseaux neuronaux responsables du cycle veille-sommeil”, Lyon, France;2. University Lyon 1, Lyon, France;1. Behavioural Neurodynamics Group, Leibniz Institute for Molecular Pharmacology (FMP)/NeuroCure Cluster of Excellence, Chariteplatz 1, CCO, 10117 Berlin, Germany;2. Neuronal Circuits and Behavior Research Group, Max Planck Institute for Metabolism Research, Gleueler Str. 50, 50931 Cologne, Germany;3. Center for Systems Neuroscience, Department of Psychological and Brain Sciences and Graduate Program for Neuroscience, Boston University, 2 Cummington Mall, Boston, MA, 02215 USA;4. Department of Psychology, University of Durham, DH1 3LE, UK;5. Department of Neuroscience, Physiology and Pharmacology, University College London, London, WC1E 6BT, UK;6. Department of Cell and Developmental Biology, Physiology and Pharmacology, University College London, London, WC1E 6BT, UK;1. Human and Evolutionary Biology Section, Department of Biological Sciences, University of Southern California, 3616 Trousdale Parkway, AHF-252, Los Angeles, CA 90089-0372, USA;2. Neurobiology Section, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA;3. Neuroscience Graduate Program, University of Illinois, Chicago, IL 60612, USA;4. Neuroscience Graduate Program, University of Southern California, Los Angeles, CA 90089, USA;5. Program in Neuroscience, Department of Integrative Physiology and Neuroscience, Washington State University, Pullman, WA 99164, USA;6. Department of Pathology, University of Washington, Seattle, WA 98195, USA
Abstract:The anatomical and functional mapping of lateral hypothalamic circuits has been limited by the numerous cell types and complex, yet unclear, connectivity. Recent advances in functional dissection of input-output neurons in the lateral hypothalamus have identified subset of inhibitory cells as crucial modulators of both sleep-wake states and metabolism. Here, we summarize these recent studies and discuss the multi-tasking functions of hypothalamic circuitries in integrating sleep and metabolism in the mammalian brain.
Keywords:Sleep  Metabolism  Food intake  Melanin concentrating hormone  GABA  Hypocretin  Orexin  Histamine
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