Challenges in comparing the acute cognitive outcomes of high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) vs. electroconvulsive therapy (ECT) in major depression: A systematic review |
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Affiliation: | 1. University of Bremen, Germany;2. University of Limerick, Ireland;3. University of New South Wales, Black Dog Institute, St. George Hospital, Australia |
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Abstract: | The present study aimed to systematically compare the cognitive outcomes of high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) and electroconvulsive therapy (ECT) in head-to-head studies with major depression (MDD) patients. A systematic literature search identified six studies with 219 MDD patients that were too heterogeneous to reliably detect meaningful differences in acute cognitive outcomes after ECT vs. HF-rTMS. Cognitive effects of brain stimulation vary depending on the timeframe and methods of assessment, stimulation parameters, and maintenance treatment. Thus, acute and longer-term differences in cognitive outcomes both need to be investigated at precisely defined timeframes and with similar instruments assessing comparable functions. |
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Keywords: | High-frequency repetitive transcranial magnetic stimulation (HF-rTMS) Electroconvulsive therapy (ECT) Cognition Major depressive disorder (MDD) |
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