Effect of a single bout of aerobic exercise on high-fat meal-induced inflammation |
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| Affiliation: | 1. The Interdepartmental Graduate Program in Nutritional Sciences, Iowa State University, Ames, IA;2. Department of Kinesiology, Iowa State University, Ames, IA;3. The Immunobiology Interdepartmental Graduate Program, Iowa State University, Ames, IA;1. Clinical Research Unit, Khoo Teck Puat Hospital, Singapore 768828;2. Diabetes Centre, Khoo Teck Puat Hospital, Singapore 768828;3. Division of Endocrinology, Department of Medicine, Khoo Teck Puat Hospital, Singapore 768828;4. Division of Nephrology, Department of Medicine, Khoo Teck Puat Hospital, Singapore 768828;5. Yishun Polyclinic, National Healthcare Group, Singapore 768796;1. Pediatric Endocrinology and Diabetes, Maine Medical Center, Portland, ME, USA;2. Center for Outcomes Research and Evaluation, Maine Medical Center Research Institute, Portland, ME, USA;3. Obesity Prevention Program, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA;4. Diabetes Unit, Massachusetts General Hospital, Boston, MA;5. Department of Medicine, Beth Israel Deaconess Hospital, Boston, MA, USA;6. Department of Nutrition, Harvard School of Public Health, Boston, MA, USA;1. Department of Endocrinology, Odense University Hospital, Odense, Denmark;2. Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark;3. Center for Pregnant Women with Diabetes, Department of Obstetrics, Rigshospitalet, Copenhagen, Denmark;4. The Institute of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark;5. Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark;6. Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark;7. Department of Gynecology and Obstetrics, Hilleroed hospital, Hilleroed, Denmark;8. Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark;9. Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, Copenhagen, Denmark;10. Medical Research Lab., Department of Clinical Medicine, Aarhus University, Aarhus, Denmark;11. Section of Molecular Diabetes & Metabolism, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark;12. Department of Gynecology and Obstetrics, Odense University Hospital, Odense, Denmark;1. Institut de Recerca Biomèdica (IRB) de Lleida, Lleida, Spain;2. Infectious Diseases Unit, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain;3. Departament de Bioquímica i Biomedicina Molecular and Institut de Biomedicina (IBUB), Universitat de Barcelona, and CIBER Fisiopatología de la Obesidad y Nutrición, Barcelona, Spain;4. Infectious Diseases Unit, Department of Internal Medicine, Hospital Universitari Joan XXIII. IISPV. Universitat Rovira i Virgili, Tarragona, Spain;5. Department of Infectious Diseases, Hospital Universitari Arnau de Vilanova, Lleida, Spain;6. Department of Infectious Diseases, Hospital Universitari de Santa María, Lleida, Spain;7. Universitat de Lleida, Lleida, Spain;1. Department of Cardiovascular Surgery, Inselspital, Bern University Hospital, University of Bern, Switzerland;2. Center of Laboratory Medicine, University Institute of Clinical Chemistry, University Hospital, Inselspital, Bern, Switzerland |
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| Abstract: | Background and aimsChronic low-grade inflammation is involved in the development of metabolic disorders including atherosclerosis, type 2 diabetes (T2D) and metabolic syndrome. Aerobic exercise has been shown to be anti-inflammatory and attenuate postprandial blood lipids, however, the effect of exercise on postprandial inflammation remains unclear. The aim of this study was to determine the protective effect of a single bout of aerobic exercise against postprandial lipemia and peripheral blood mononuclear cell (PBMC) inflammation and to evaluate associations with changes in the energy-sensing enzyme, AMP-activated protein kinase (AMPK).Materials and methodsHealthy male subjects (n = 12, age = 23 ± 2, %Fat = 19 ± 2) reported to the laboratory following an overnight fast (12–14 h) on two separate occasions for consumption of a high-fat meal (HFM). Participants completed an acute bout of aerobic exercise the afternoon prior to one of the HFM visits.Results and conclusionResults indicate that the single bout of moderate aerobic exercise increased AMPK signaling in PBMCs, as shown by increased phosphorylated acetyl-CoA carboxylase (p-ACC). This may be due to decreases in the AMPK inhibitory kinases PKD and GSK3β. Additionally, prior moderate intensity exercise decreased postprandial lipemia (PPL) and some mediators of the inflammatory pathway, such as p-NF-κB. These findings that acute aerobic exercise improves AMPK and NF-κB signaling in human PBMCs contribute support to the anti-inflammatory roles of exercise. |
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