| BET蛋白与脑认知功能关系的研究进展 |
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| 引用本文： | 孟辉,邹广菁,黄伏连. BET蛋白与脑认知功能关系的研究进展[J]. 南华大学学报(医学版), 2023, 0(1): 146-149 |
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| 作者姓名： | 孟辉 邹广菁 黄伏连 |
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| 作者单位： | 益阳医学高等专科学校,湖南益阳 413000;中南大学基础医学院人体解剖与神经生物学系,湖南长沙 410013 |
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| 基金项目： | 国家自然科学基金青年项目(82200099);湖南省自然科学基金面上项目(2022JJ30577);湖南省教育厅科学研究项目(21C1496,19C1833) |
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| 摘 要： | 溴结构域和超末端结构域(BET)蛋白能识别乙酰化组蛋白并与之结合,同时与染色质调节因子相互作用或招募转录起始复合物,从而启动基因转录。近几年,BET蛋白抑制剂的合成推进了BET蛋白相关表观遗传学研究。本文综述BET蛋白的结构和功能、BET蛋白抑制剂、BET蛋白在学习和记忆中的作用、BET蛋白在老年痴呆症中的作用以及BET蛋白在药物成瘾中的作用。
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| 关 键 词： | BET蛋白 组蛋白乙酰化 学习与记忆 表观遗传学 [ |
| 收稿时间： | 2022-05-01 |
| 修稿时间： | 2022-11-23 |
Research progress on the relationship between BET proteins and brain cognitive function |
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| MENG Hui,ZOU Guangjing,HUANG Fulian. Research progress on the relationship between BET proteins and brain cognitive function[J]. Journal of Nanhua University(Medical Edition), 2023, 0(1): 146-149 |
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| Authors: | MENG Hui ZOU Guangjing HUANG Fulian |
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| Affiliation: | Yiyang Medical College, Yiyang 413000, Hunan, China;Department of Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Changsha 410013, Hunan, China |
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| Abstract: | Bromine domain and hyperterminal domain (BET) proteins recognize and bind to acetylated histones and interact with chromatin regulatory factors or recruit transcription initiation complexes to initiate gene transcription. In recent years, the synthesis of BET inhibitors has greatly promoted the epigenetic research related to BET proteins. This paper reviews the structure and function of BET protein family, BET inhibitors, and the role of BET proteins in learning and memory, Alzheimer''s disease and drug addiction. |
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| Keywords: | BET proteins histone acetylation learning and memory epigenetics |
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