| 左旋精氨酸对家兔心肌缺血再灌注损伤的保护作用 |
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| 引用本文： | 王万铁,林丽娜,徐正祄 ,李东,王宗敏,王卫.左旋精氨酸对家兔心肌缺血再灌注损伤的保护作用[J].中国介入心脏病学杂志,1999(2). |
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| 作者姓名： | 王万铁 林丽娜 徐正祄 李东 王宗敏 王卫 |
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| 作者单位： | 温州医学院病理生理教研室，温州医学院附属一院麻醉科，温州医学院检验系分析中心，温州医学院附属二院病理科 |
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| 摘 要： | 目的探讨左旋精氨酸（Ｌ－Ａｒｇ）对心肌缺血再灌注损伤（ＭＩＲＩ）的保护作用。方法制备家兔ＭＩＲＩ模型，观察Ｌ－Ａｒｇ对血清中和心肌组织中一氧化氮代谢产物（ＮＯＰ）含量、乳酸脱氢酶（ＬＤＨ）活性及心肌细胞形态学变化的影响。结果Ｌ－Ａｒｇ保护组和非保护组比较，血清及心肌ＮＯＰ明显升高（Ｐ＜０．０５）；心肌ＬＤＨ显著增高（Ｐ＜０．０５），而血清ＬＤＨ无明显变化；心肌细胞形态学异常改变明显减轻。结论Ｌ－Ａｒｇ通过提高机体一氧化氮水平而保护缺血再灌注损伤的心肌。
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| 关 键 词： | 左旋精氨酸 缺血再灌注损伤 一氧化氮 |
Protective effect of L Arginine on myocardial ischemia reperfusion injury in rabbits |
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| Wang Wantie,Lin Lina,Xu Zhengjie,et al.Protective effect of L Arginine on myocardial ischemia reperfusion injury in rabbits[J].Chinese Journal of Interventional Cardiology,1999(2). |
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| Authors: | Wang Wantie Lin Lina Xu Zhengjie |
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| Institution: | Wang Wantie,Lin Lina,Xu Zhengjie,et al Department of Pathophysiology,Wenzhou Medical College,Wenzhou 325003 |
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| Abstract: | Objective To exprole the protective effects of L Arginine (L Arg) on myocardial ischemia reparfusion reperfusion injury (MIRI) Methods Using a MIRI model, the effects of L Arg on nitric oxide protects (NOP) content and lactic dehydrogenase (LDH) activity in serum and myocardium and morhological changes of myocardial cell were observed during MIRI in rabbits Results The group protected with L Arg, as compared with the nonprotective group, showed that NOP content in serum and myocardium increased significantly ( P <0 05) and LDH activity in serum decreased lightly ( P >0 05), while LDH activity in myocardium elevated significantly ( P <0 05), meanwhile abnormal changes of myocardial cell morphologically were remarkably ameliorated Conclusion L Arg had notable protective effects on postischemia reperfusion myocardium, which was due to its raising NO level |
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| Keywords: | L Arginine Nyocardium Ischemia reperfusion injury Nitric oxide |
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