| HIF-1调节机制在糖尿病视网膜血管及神经病变中的研究进展 |
| |
| 引用本文： | 吴宏禧,游志鹏. HIF-1调节机制在糖尿病视网膜血管及神经病变中的研究进展[J]. 国际眼科杂志, 2009, 9(10): 1937-1940. DOI: 10.3969/j.issn.1672-5123.2009.10.030 |
| |
| 作者姓名： | 吴宏禧 游志鹏 |
| |
| 作者单位： | 南昌大学第二附属医院眼科, 中国江西省南昌市,330006;南昌大学第二附属医院眼科, 中国江西省南昌市,330006 |
| |
| 摘 要： | 糖尿病视网膜病变的实质是进展性的微血管病变,新生血管形成是其特征性的病理改变。在高糖和低氧环境下,低氧诱导因子-1α(HIF-1α)在血管新生和视神经纤维受损中起重要作用,它通过诱导VEGF和p53上调,从而促进眼内新生血管的发生和发展,同时也促使视网膜神经细胞抑制和凋亡。故本文对HIF-lα在糖尿病视网膜疾病中的研究进展作一综述。
|
| 关 键 词： | 低氧诱导因子-1α 糖尿病视网膜病变 血管内皮生长因子 新生血管 p53基因 |
Study progress of HIF-1 regulation mechanisms in diabetic retinopathy and neuropathy |
| |
| Hong-Xi Wu,Zhi-Peng You. Study progress of HIF-1 regulation mechanisms in diabetic retinopathy and neuropathy[J]. International Eye Science, 2009, 9(10): 1937-1940. DOI: 10.3969/j.issn.1672-5123.2009.10.030 |
| |
| Authors: | Hong-Xi Wu Zhi-Peng You |
| |
| Affiliation: | Department of Ophthalmology,the Second Affiliated Hospital of Nanchang University,Nanchang 330006,Jiangxi Province,China |
| |
| Abstract: | ·The essence of diabetic retinopathy is progressive microangiopathy whose characteristic pathological change is neovascularization.In high glucose and hypoxic conditions,hypoxia-inducible factor-1α(HIF-1α)plays an important role in angiogenesis and damage of the optic nerve fibers.Through the induction of VEGF and p53 up-regulation,it can promote intraocular neovessels occurrence and development,which causes retinal ganglion cell inhibition and apoptosis.Therefore,the progression of HIF-lα in diabetic retinopathy disease were reviewed in this article.· |
| |
| Keywords: | hypoxia inducible factor-1α diabetic retinopathy vascular endothelial growth factor neovascularization p53 gene |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
