氟脱氧葡萄糖正电子发射型体层摄影术在非小细胞肺癌适形放疗中的应用研究

目的探讨氟脱氧葡萄糖(FDG)正电子发射型体层摄影术(PET)在非小细胞肺癌(NSCLC)三维适形放疗定位中的辅助作用。方法13例非小细胞肺癌患者行FDG PET和CT检查，利用CT和FDG PET-CT图像融合软件分别勾画大体肿瘤体积(GTVCT和GTVPET-CT)，并对两者进行比较。结果13例患者除2例外，其他患者的GTVCT和GTVPET-CT均不同，其中5例GTVPET-CT大于GTVCT，平均增加29．2cm^3；6例GTVPET-CT小于GTVCT，平均减少41．6cm^3。结论与单纯CT图像相比，FDG PET-CT融合图像不仅能更好地分清肿瘤与正常组织，而且对纵隔淋巴结具有更高的敏感性和特异性。

Image fusion between 18 F-deoxyglucose-positron emission tomography and CT in conformal radiotherapy for non-small-cell lung carcinoma

Objective To study 18F-deoxyglucose-positron emission tomography and CT fusion (FDG PET) in three dimensional conformal radiotherapy for non-small -c ell lung carcinoma (NSCLC). Methods Gross tumor volume (GTV) of 13 NSCLC patient s were determined by FDG PET and CT separately (GTV PET-CT and GTV CT ), which were then compared. Results Except 2 patients, all the other patients' GTV PET-CT dif fered from their GTV CT. Compared with GTV CT, GTV PET-CT was in creased by an avera ge of 29.2?cm3 in 5 patients and decreased by an average of 41.6?cm3 in 6 patien ts. Conclusions 18F-deoxyglucose-positron emission tomography, which can improve target definition between benign and malignant lesions in the lung, is proved t o be more sensitive and specific in detecting mediastinal lymph node involvement . FDG PET may provide accurate target definition and improve the local control.