维吾尔族支气管哮喘患者血清总IgE及ECP水平的研究

目的:探讨维吾尔族血清总免疫球蛋白 E(T- Ig E)、变应原特异性 Ig E抗体 (S- Ig E)及嗜酸粒细胞阳离子蛋白 (ECP)与支气管哮喘发病的关系。方法 :将和田部分地区 2 12例 18～ 72岁维吾尔族人分为对照组、哮喘间歇发作组及轻度、中度、重度哮喘组 ,分别定量测定 5组患者的血清 ECP(S- ECP)、T- Ig E水平 ,同时对吸入性变应原的特异性 Ig E抗体水平进行定性测定。结果:哮喘各组之间 S- ECP水平差异均有统计学意义 (P均 <0 .0 1) ,重度哮喘患者组 S- ECP水平最高 ,且 S- ECP水平与病情严重程度呈正相关关系 (r=0 .6 3,P <0 .0 1)。变态反应的出现与 S- ECP水平增高有关 ,T- Ig E与 S- ECP呈正相关关系 (r =0 .6 1,P <0 .0 1)。S- ECP水平与哮喘发作的自觉症状和通过检查所得的客观体征具有高度相关性 ,ECP与最大峰流速 (PEF)之间存在负相关关系 (r =- 0 .6 7,P <0 .0 5 )。结论:血清 S- ECP和 T- Ig E二者的水平及其相互关系主要取决于嗜酸粒细胞激活程度和分泌蛋白的能力 ,它们能反映哮喘气道炎症的活动情况 ,并可预示哮喘发作的严重程度。

Correlation between serum measurements of ECP、T-IgE and S-IgE with bronchial asthma in the Uygur population

Objective: To explore serum ECP,T-IgE and S-IgE levels of Xinjiang Uygur population,to study the correlation and their clinical significance in asthmatic patients in different degrees,and to elucidate the role of ECP and IgE in the pathogenesis of bronchial asthma. Methods: 123 Uyger asthmatics and 89 normal healthy controls with the same ethnic nearby Hetian region Xinjiang were investigated. The serum ECP and total IgE and specific aeroallergen were detected using a pharmacia UniCAP 100 type instrument,pulmonary ventilatory function assessed by FEV1 and PEF. Results: The positive rate of specific IgE antibody in asthmatics was 17.89%(22/123). The increased rate of ECP in asthmatics with positive specific IgE was higher than that with negative specific IgE. Our data showed that the levels of S-ECP and T-IgE in moderate to severe asthma patients were significantly higher than in mild cases and control group (P<0.01);the highest values were found in the severe asthma group. A significant correlation between S-ECP and symptom score and T-IgE were observed among participants (P<0.01). S-ECP had an additive value in predicting the occurrence of asthma. Furthermore,S-ECP showed good correlation to subjective and objective measures of asthma activity as well as there was negative correlation between S-ECP and PEF. Conclusions: ECP can be an inflammatory mediator,S-ECP may be of value in assessing the activity of asthma. They might participate in the exacerbation of asthma. They can become effective means of monitoring the severity of disease and conducting antiinflammation.