免疫吸附清除循环肿瘤坏死因子-α的可行性

为评价抗肿瘤坏死因子－α（ＴＮＦ－α）单克隆抗体亲和免疫吸附剂临床应用的前景，通过体内、外实验，探讨了该免疫吸附治疗的安全性和可行性。结果表明，该免疫吸附剂机械性能好，极少抗体配基脱落，可耐受醇类化学消毒，粗试生物相容性好，为将来临床应用免疫吸附治疗内毒素休克等ＴＮＦ过度升高的有关疾病奠定了基础

FEASIBILITY OF SPECIFIC REMOVAL OF CIRCULATING TNF BY IMMUNOABSORPTION

From different points of view, we studied the safety and feasibility of the immunoabsorption with anti TNF monoclonal antibodies immobilized immunosorbent through experiments in vitro and in vivo , in order to evaluate its possibility for clinical use. Results showed: (1)The immunosorbent had perfect physical performance; (2)Leakage of antibody was not detectable; (3) The sorbent capacity was not affected obviously when the immunosorbent was disinfected with ethanol; (4) The immunosorbent was of good biocompatibility.