Photodynamic therapy in colorectal cancer treatment—The state of the art in preclinical research |
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| Institution: | 1. Department of Laser Medicine, Chinese PLA General Hospital, Beijing 100853, PR China;2. Department of Genetics, Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA;3. Department of Dermatology, the Second Hospital, Shanxi Medical University, Taiyuan 030001,PR China;4. Wan Fang Hospital, Taipei Medical University, Taipei 116, Taiwan;5. School of Public Health, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA;6. College of Medicine, University of South Alabama, Mobile 36688, USA;7. Department of Oncology, Chinese PLA General Hospital, Beijing 100853, PR China;1. Nizhny Novgorod State Medical Academy, 603005 Nizhny Novgorod, Russian Federation;2. Lobachevsky State University, 603000 Nizhny Novgorod, Russian Federation;3. Semenov Institute of Chemical Physics, Russian Academy of Sciences, 119991 Moscow, Russian Federation;4. Institute for Regenerative Medicine, I.M. Sechenov First Moscow State Medical University, 119991 Moscow, Russian Federation;5. Institute of Photonic Technologies, Research center “Crystallography and Photonics”, Russian Academy of Sciences, 142190 Troitsk, Moscow, Russian Federation;1. Université de Limoges, Laboratoire de Chimie des Substances Naturelles, EA 1069, 123 Avenue Albert Thomas, F-87060 Limoges, France;2. Université de Limoges, Homéostasie Cellulaire et Pathologie, EA 3842, 2 rue du Docteur Marcland, F-87025 Limoges, France;3. Université de Limoges, CIM, UMR CNRS 7276, 2 rue du Dr Marcland, F-87000 Limoges, France;4. Laboratoire de recherche et d''analyses de la Haute-Vienne, Avenue du Professeur Joseph de Léobardy, 87005 Limoges, France;1. Department of Chemical and Biomolecular Engineering, Sogang University, 35 Baekbeom-ro, Mapo-gu, Seoul 04107, Republic of Korea;2. Center for Photomedicine, Department of Biotechnology, The Catholic University of Korea, Bucheon-si, Gyeonggi-do 14662, Republic of Korea;3. Department of Biomedical Engineering, Sogang University, 35 Baekbeom-ro, Mapo-gu, Seoul 04107, Republic of Korea |
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| Abstract: | BackgroundPhotodynamic therapy (PDT) is used in many different oncologic fields. Also in gastroenterology, where have been a few attempts to treat both the premalignant lesion and advanced colorectal cancer (CRC). This review aims to give a general overview of preclinical photodynamic studies related to CRC cells and animal studies of photodynamic effects related to CRC treatment to emphasize their potential in study of PDT mechanism, safety and efficiency to translate these results into clinical benefit in CRC treatment.Materials and methodLiterature on in vitro preclinical photodynamic studies related to CRC cells and animal studies of photodynamic effects related to CRC treatment with the fallowing medical subject headings search terms: colorectal cancer, photodynamic therapy, photosensitizer(s), in vitro, cell culture(s), in vivo, animal experiment(s). The articles were selected by their relevance to the topic.ResultsThe majority of preclinical studies concerning possibility of PDT application in colon and rectal cancer is focused on phototoxic action of photosensitizers toward cultured colorectal tumor cells in vitro. The purposes of animal experiments are usually elucidation of mechanisms of observed photodynamic effects in scale of organism, estimation of PDT safety and efficiency and translation of these results into clinical benefit.Concluding remarksIn vitro photodynamic studies and animal experiments can be useful for studies of mechanisms and efficiency of photodynamic method as a start point on PDT clinical research. The primary disadvantage of in vitro experiments is a risk of over-interpretation of their results during extrapolation to the entire CRC. |
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| Keywords: | Colorectal cancer Cancer treatment Photodynamic therapy Preclinical research Cell cultures Animal experiments |
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