Macrocystis pyrifera ferment-containing creams for optimizing facial skin rejuvenation |
| |
| Authors: | Michael Gold MD FAAD Yoon-Soo Cindy Bae MD FAAD David J. Goldberg MD JD FAAD Sumayah Jamal MD PhD Amy B. Lewis MD Shari Marchbein MD FAAD Adriana Ros DO Uma Santhanam PhD Lisa DiNatale Jaime Emmetsberger PhD |
| |
| Affiliation: | 1. Gold Skin Care Center, Nashville, Tennessee, USA;2. Laser & Skin Surgery Center of New York, New York, New York, USA;3. Schweiger Dermatology Group, Hackensack, New Jersey, USA;4. Schweiger Dermatology Group, New York, New York, USA;5. Lewis Dermatology & Associates, New York, New York, USA;6. NYU School of Medicine, New York, New York, USA;7. Dermatology Institute and Laser Center, Clifton, New Jersey, USA;8. The Estee Lauder Companies, Melville, New York, USA;9. The Estee Lauder Companies, Melville, New York, USA La Mer, Max Huber Research Labs, Melville, New York, USA |
| |
| Abstract: | Background There is an increasing demand for facial skin rejuvenation. Specialized aesthetic skincare treatments may be one of the first steps to help prevent or treat facial signs of aging. This article discusses aesthetic skin care for facial skin rejuvenation, particularly data on two creams containing Macrocystis pyrifera ferment. Methods The authors convened a dermatology advisory board to discuss challenges and practices in using skincare for facial rejuvenation, combining their expert opinion and experience on facial rejuvenation with preclinical and clinical data on two creams containing Macrocystis pyrifera ferment and a review of the literature. Results Preclinical and clinical studies on Macrocystis pyrifera ferment and two creams containing the ferment exhibit anti-inflammatory, anti-aging, and healing properties. In preclinical studies, the ferment demonstrated collagen type I enhancing properties in ex vivo skin models, and skin cells treated with the ferment migrated faster than untreated cells in the in vitro study. In clinical studies measuring visible anti-inflammatory activity, the ferment alone and the ferment-containing products significantly decreased erythema, and in anti-aging studies, they improved visible skin aging parameters. Finally, in clinical studies on the stratum corneum, the two creams increased moisture levels and decreased transepidermal water loss (TEWL), reflecting healing by enhancing barrier strength and recovery. Conclusions The Macrocystis pyrifera ferment and creams containing the ferment are effective skin care treatment products to decrease the visible effects of inflammation and signs of aging while promoting healing by enhancing barrier resilience and recovery. |
| |
| Keywords: | Creams facial rejuvenation skin care |
|
|
