| 原发性胆汁性肝硬化免疫分子机制研究进展 |
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| 引用本文： | 尤玉琴,孔祥平. 原发性胆汁性肝硬化免疫分子机制研究进展[J]. 传染病信息, 2012, 25(2): 126-128 |
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| 作者姓名： | 尤玉琴 孔祥平 |
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| 作者单位： | 解放军第四五八医院全军肝病中心,广州,510600 |
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| 基金项目： | 国家重点基础研究发展计划(973计划) |
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| 摘 要： | 原发性胆汁性肝硬化(primary biliary cirrhosis,PBC)是一种免疫介导损伤胆管上皮细胞及肝内小胆管的胆汁淤积性自身免疫性肝病,具有发展为肝硬化的倾向.多种免疫相关基因通过影响疾病易感性、免疫调节等途径,促使PBC的发生、发展.本文就PBC的免疫分子机制研究动态进行综述.
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| 关 键 词： | 肝硬化,胆汁性 自身免疫 分子生物学 |
Research progress of immunological and molecular mechanism of primary biliary cirrhosis |
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| YOU Yu-qin , KONG Xiang-ping. Research progress of immunological and molecular mechanism of primary biliary cirrhosis[J]. Infectious Disease Information, 2012, 25(2): 126-128 |
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| Authors: | YOU Yu-qin KONG Xiang-ping |
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| Affiliation: | * PLA Center of Liver Diseases,458 Hospital of PLA,Guangzhou,Guangdong 510600,China |
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| Abstract: | Primary biliary cirrhosis(PBC) is an autoimmune cholestatic liver disease in which an immune-mediated injury tar-gets bile duct epithelial cells and small intrahepatic bile ducts.It has a tendency to develop liver cirrhosis.Various immune-related genes promote the occurrence and development of PBC by affecting the susceptibility of the disease and immune regulation.This re-view focuses on the research dynamics of immunological and molecular mechanisms of PBC. |
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| Keywords: | liver cirrhosis,biliary autoimmunity molecular biology |
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