| ω-3多不饱和脂肪酸逆转肠外营养所致肝损害的实验室观察 |
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| 引用本文： | 胥子玮,李幼生,王剑,吴波,李元新,黎介寿. ω-3多不饱和脂肪酸逆转肠外营养所致肝损害的实验室观察[J]. 肠外与肠内营养, 2012, 19(4): 193-196 |
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| 作者姓名： | 胥子玮 李幼生 王剑 吴波 李元新 黎介寿 |
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| 作者单位： | 1. 南京大学医学院临床学院(南京军区南京总医院)解放军普通外科研究所 江苏南京210002
2. 南京大学医学院临床学院(南京军区南京总医院)病理科,江苏南京,210002 |
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| 摘 要： | 目的:从临床实验室和组织学观察ω-3多不饱和脂肪酸(ω-3PUFA)对成人肠外营养相关肝损害(PNALD)的作用.方法:选取15例长期行PN导致胆汁淤积(直接胆红索≥34μmol/L)的成人短肠综合征病人.动态观察病人应用ω-3PUFA前和治疗1个月内肝功能和血清游离脂肪酸谱的变化.同时行肝穿刺活检,观察治疗前和治疗1...
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| 关 键 词： | ω-3多不饱和脂肪酸 鱼油 肠外营养相关肝损害 短肠综合征 胆汁淤积 |
Effect of omega-3 polyunsaturated fatty acids to reverse biopsy-proven parenteral nutrition associated liver disease in adults |
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| XU Zi-wei , LI You-sheng , WANG Jian , WU Bo , LI Yuan-xin , LI Jie-shou. Effect of omega-3 polyunsaturated fatty acids to reverse biopsy-proven parenteral nutrition associated liver disease in adults[J]. Parenteral & Enteral Nutrition, 2012, 19(4): 193-196 |
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| Authors: | XU Zi-wei LI You-sheng WANG Jian WU Bo LI Yuan-xin LI Jie-shou |
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| Affiliation: | 1(1.Research Institute of General Surgery;2.Department of Pathology,Clinical School of Medicine College of Nanjing University/Nanjing General Hospital of Nanjing Military Command,PLA,Nanjing 210002,Jiangsu,China) |
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| Abstract: | Objective: To investigate the effects of ω-3PUFA supplemented intravenous lipid emulsion(ILE) on PNALD in adults.Methods: We performed an open-labeled study of a ω-3PUFA-based ILE in 15 adults with SBS who developed cholestasis(serum direct bilirubin≥2 mg/dL) while receiving soybean oil-based ILE.Liver biopsy was performed before and one month after the initiation of ω-3PUFA to confirm the presence and improvement of cholestasis.Blood samples were collected every week for analysis of fatty acid composition and liver function.Results: 12 of the 15 patients had their direct bilirubin normalized within 4 weeks and direct bilirubin markedly decreased over time in our study.There were ameliorations of functional hepatic indexes and fatty acids pattern in all adults patients and serial liver biopsy specimens showed progressive histologic improvement.Conclusion: Parenteral ω-3PUFA based fat emulsions are safe and effective in the treatment of PNALD in adults. |
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| Keywords: | Omega-3 polyunsaturated fatty acids Fish oil Parenteral nutrition associated liver disease Short bowel syndrome Cholestasis |
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