| Abstract: | The character of the hyperlipidemia was studied in rats with chronic uremia caused by removal of five-sixths of the total weight of kidney tissue. The blood cholesterol and phospholipid concentrations were almost twice the normal level 13–30 days after subtotal nephrectomy in the rats with uremia. The hyperlipidemia was more marked when the blood nonprotein nitrogen level was high. The serum triglyceride concentration was not increased. The total concentration of serum  -and pre--lipoproteins, determined nephelometrically, was significantly increased only if the nonprotein nitrogen exceeded 80 mg%. Disk electrophoresis of the serum lipoproteins of the rats with uremia revealed a definite increase in the  -lipoprotein concentration and a very small increase in the -lipoprotein concentration. Postheparin plasma lipolytic activity in the rats with uremia was normal. Massive proteinuria was observed in the experimental rats, but the hypoproteinemia was not significant.Nephrology Problem Laboratory, I. M. Sechenov First Moscow Medical Institute. Pathomorphological Laboratory, Institute of Nutrition, Academy of Medical Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR E. M. Tareev.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 85, No. 6, pp. 676–679, June, 1978. |
