先心病肺动脉高压肺动脉平滑肌细胞钙离子含量的试验研究

目的探讨平滑肌细胞游离Ca2+含量与肺动脉高压的关系,为临床选择更为有效的早期干预措施提供依据。方法采用流式细胞术分别检测先天性心脏病合并肺动脉高压的患儿18例、先天性心脏病未合并肺动脉高压的患儿19例肺动脉平滑肌细胞内钙离子含量。结果肺动脉高压组中肺动脉平滑肌细胞钙含量较非肺动脉高压组高,有显著性差异。结论通过测量肺动脉平滑肌细胞钙含量对于研究肺动脉平滑肌细胞钙转运异常与先心病肺动脉高压的发病机制之间的关系有着重要意义。

Research in the Pulmonary Artery smooth muscle cell Calcium Contents in Congenital Heart Disease Pulmonary Hypertension

Objective Observe relationship between Ca2+ contents in smooth muscle cell and PH. Study developmental mechanism of PH. Methods Flow cytometry was performed to detect Ca2+ in pulmonary muscle cell. These groups including 18 congenital heart disease patients with PH and 19 patients without PH. There are 22 normal children as control. Results Ca2+ in red blood cell in CHD with PH group is higher than in CHD without PH group and health control group. There was significant difference between them (P<0.01). C...