张家口地区慢性丙型肝炎患者甲型肝炎病毒感染情况分析

目的分析张家口地区慢性丙型肝炎患者中甲型肝炎病毒(HAV)的流行情况,为疾病控制和治疗提供依据。方法选取2010年3月至2012年6月张家口地区万全县中医院、河北北方学院第一附属医院及解放军251医院收治的83例慢性丙型肝炎患者作为研究对象,收集其详细临床资料,应用酶联免疫吸附试验法检测受试者血清中HAV IgM抗体水平,并对所得数据进行统计分析。结果慢性丙型肝炎患者中HAV IgM总阳性率为48.2%;不同年龄段患者HAV合并感染率比较差异无统计学意义(P>0.05);患者性别、受教育程度及有无静脉注射毒品史的特征与HAV IgM阳性率之间差异无统计学意义(P>0.05)。结论张家口地区丙型肝炎合并甲型肝炎感染率非常高,临床危害大,对确诊的丙型肝炎患者接种甲型肝炎疫苗以产生足够的免疫反应是非常必要的。

Analysis of Hepatitis A Infection in Patients with Chronic Hepatitis C in Zhangjiakou Area

Objective To evaluate prevalence of HAV in patients with chronic HCV in Zhangjiakou area, and provide certain basis for the disease control and treatment. Methods Eighty-three patients with chronic HCV in Zhangjiakou from Wanquan County Hospital of Traditional Chinese Medicine, the First Affiliated Hospi- tal of Hebei North College and he 251st Hospital of PLA were selected as objects from Mar. 2010 to Jun. 2012. The clinical data of the objects were collected, and ELISA were used to analyze HAV IgM antibody level. Statis- tical analysis was done. Results The HAV IgM incidence was 48.2% in patients with chronic HCV. The prev- alence of HAV combined infection between different age groups was not statistically significantly different （ P 〉 0.05 ）. HAV IgM positive rate saw no statistically significant difference between different patient genders, education levels and intravenous drug use history（ P 〉 0.05 ）. Conclusion Patients with HCV infection are at high risk of getting HAV in Zhangjiakou area. HAV vaccination program should be performed in HAV seronega- tive patients with HCV to produce an adequate immune response.