| 氟康唑耐药的白念珠菌对唑类药物交叉耐药实验 |
| |
| 引用本文： | 吴颖,刘伟,万哲,李若瑜.氟康唑耐药的白念珠菌对唑类药物交叉耐药实验[J].中国皮肤性病学杂志,2009,23(3). |
| |
| 作者姓名： | 吴颖 刘伟 万哲 李若瑜 |
| |
| 作者单位： | 1. 云南省第一人民医院皮肤科,云南,昆明,650032
2. 北京大学第一医院皮肤科,北京,100034 |
| |
| 摘 要： | 目的观察对氟康唑耐药的外阴阴道念珠菌病(VVC)白念珠菌对其他唑类药物的敏感性和交叉耐药性。方法用CLSI颁布的M27-A2方案检测氟康唑(FLC)、伊曲康唑(ITC)、伏立康唑(VRC)及联苯苄唑(B IF)对VVC分离的耐FLC白念珠菌的最低抑菌浓度(M IC)。结果19株VVC分离白念珠菌中有11株对FLC,ITC交叉耐药,有5株对FLC,ITC,VRC交叉耐药。结论VVC分离白念珠菌对唑类药物存在交叉耐药性,尤其在FLC与ITC之间明显。
|
| 关 键 词： | 白念珠菌 唑类药 交叉耐药 药敏试验 |
Fluconazole-resistant Candida Albicans Strains Exhibited Cross-resistance to Other Azole Antifungal Agents in Vitro |
| |
| WU Ying,LIU Wei,WAN Zhe,LI Ruo-yu.Fluconazole-resistant Candida Albicans Strains Exhibited Cross-resistance to Other Azole Antifungal Agents in Vitro[J].The Chinese Journal of Dermatovenereology,2009,23(3). |
| |
| Authors: | WU Ying LIU Wei WAN Zhe LI Ruo-yu |
| |
| Abstract: | Objective To study sensitivities and cross-resistances of fluconazole-resistant Candida albicans isolates from vulvovaginal candidiasis to other azoles.Methods Minimum inhibitory concentration(MIC) of fluconazole,itraconazole,voriconazole and bifonazole were tested by utilizing Clinical Laboratory Standards Institute(CLSI) broth microdilution methods.Results Eleven of the total 19 FLC-resistant isolates showed cross-resistances to ITC,and 5/19 FLC-resistant isolates showed cross-resistances to both ITC and VRC.Conclusions Some of the fluconazole-resistant Candida albicans isolates could have cross-resistance to other common azole antifungal agents. |
| |
| Keywords: | Candida albicans Azole antifungals Cross-resistance Antifungal susceptibility testing |
| 本文献已被 万方数据 等数据库收录！ |
|
