| 复发喉鳞状细胞癌相关基因表达谱研究 |
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| 引用本文： | 王斌全,陈彦球,温树信,夏立军,王建明,皇甫辉,龚佳蕾,何显峰. 复发喉鳞状细胞癌相关基因表达谱研究[J]. 临床耳鼻咽喉头颈外科杂志, 2003, 17(6): 339-341 |
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| 作者姓名： | 王斌全 陈彦球 温树信 夏立军 王建明 皇甫辉 龚佳蕾 何显峰 |
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| 作者单位： | 1. 山西医科大学第一医院耳鼻咽喉科,太原,030001
2. 中国科学院上海生化细胞所 |
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| 基金项目： | 卫生部科学研究基金资助项目 (No .98 2 2 6 2 ) |
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| 摘 要： | 目的：筛选与复发喉鳞状细胞癌相关的基因。方法：用包含18000个cDNA的基因芯片法检测2例复发喉鳞状细胞癌标本的癌组织及喉正常黏膜组织mRNA表达谱，通过对比分析寻找与复发喉鳞状细胞癌相关的基因。结果：①重复且相差3倍以上差异表达基因共218个，其中喉癌组织表达上调的基因137个，表达下调的基因81个；②表达相差10倍以上的基因4个，分别为U02570、AW863712、AA523939和NM_014381。结论：复发喉鳞状细胞癌的发生是一个多基因表达失调的过程，可能主要与GTP酶活化蛋白及DNA错配修复有关。
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| 关 键 词： | 喉肿瘤 癌，鳞状细胞 肿瘤复发 基因表达 |
| 文章编号： | 1001-1781(2003)06-0339-03 |
| 修稿时间： | 2002-10-16 |
Investigation on recurrent-associated gene expression pattern of recurrent-laryngeal squamous cell carcinoma |
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| WANG Binquan CHEN Yanqiu WEN Shuxin XIA Lijun WANG Jianming HUANG FU Hui GONG Jialei HE Xianfeng. Investigation on recurrent-associated gene expression pattern of recurrent-laryngeal squamous cell carcinoma[J]. Journal of clinical otorhinolaryngology, head, and neck surgery, 2003, 17(6): 339-341 |
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| Authors: | WANG Binquan CHEN Yanqiu WEN Shuxin XIA Lijun WANG Jianming HUANG FU Hui GONG Jialei HE Xianfeng |
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| Affiliation: | Department of Otorhinolaryngology, First Hospital of Shanxi Medical University, Taiyuan 030001. |
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| Abstract: | OBJECTIVE: To screen out recurrent-associated gene in expression pattern of laryngeal squamous cell carcinoma(LSCC). METHOD: By cDNA array chip containing 18,000 gene, the gene expression pattern of cancer and normal mucosal tissues in 2 cases of LSCC, were compared and analyzed. RESULT: 1. 218 genes expressed repeatedly and differentially in LSCC were discovery. Among these genes, up- and down-regulated were 137 and 81; 2. The genes whose expression difference was over 10 times were U02570, AW863712, AA523939 and NM_014381. CONCLUSION: The episode of recurrent LSCC was a process of disturbance of numerous gene expression. GTPase activating protein (U02570) and DNA mismatch repair gene(NM_014381) probably played a major role in the episode. |
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| Keywords: | Laryngeal neoplasms Carcinoma squamous cell Neoplasm recurrence Gene expression |
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