风湿性心脏病肺动脉高压患者肺动脉血浆环核苷酸水平的变化

目的：研究风心病肺动脉高压患者肺动脉血浆环核苷酸水平的变化及与血流动力学的关系，方法：用放射免疫法测定风心病患者肺动脉血浆中环磷酸腺苷和环磷酸鸟苷的水平，用PA漂浮导管和HP监护系统进行血流动力学测定。结果：风心病肺动脉高压患者肺动脉血浆中环核苷酸（环磷酸腺苷，环磷酸鸟苷）水平均显著增加，血浆环核苷酸水平与肺动脉压，肺血管阻力，肺毛细血管楔压，心排指数等密切相关。结论：血浆环核苷酸水平增高是风心病肺动脉高压患者的病理生理特征之一，环核苷酸作为第二信使可能在风心病肺动脉高压形成过程中起着重要的调节作用。

Change of plasma cyclic nucleotide in patients of rheumatic heart disease with pulmonary hypertension

Objective:To study the change of plasma cyclic nucleotide in patients of rheumatic heart disease with pulmonary hypertension and to evaluate the relationship between plasma cyclic nucleotides and hemodynamics. Methods:Plasma cGMP and cAMP were examined by radioimmunoassay, hemodynamic data were obtained with Swan Ganz catheter and the HP compact configurable monitors. Results:Plasma cyclic nucleotide increased in patients of rheumatic heart disease with pulmonary hypertension and had an obvious correlation with the level of PAPM, PVR, PAWP and CI. Conclusion:Increased cAMP and cGMP is one of the pathophysiological characters of pulmonary hypertension, cAMP and cGMP, as the second messenger, may play an important regulating role in the development of pulmonary hypertension.