Astrocytic infection in canine distemper virus-induced demyelination |
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Authors: | F. Mutinelli M. Vandevelde C. Griot A. Richard |
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Affiliation: | (1) Institut für Tier-Neurologie, Universität Bern, Bremgartenstrasse 109 A, Postfach 2735, CH-3001 Bern, Switzerland;(2) Present address: Istituto di Patologia Generale, Università di Bologna, Bologna, Italy |
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Abstract: | Summary Acute canine distemper virus (CDV)-induced demyelinating lesions were examined with double-labelling immunocytochemistry simultaneously demonstrating CDV antigen and glial fibrillary acidid protein (GFAP) as marker for astrocytes. It was shown that 64% of all astrocytes within the demyelinating lesions were infected and that 95% of all infected cells counted in the lesions were astrocytes. These results suggest that the astrocyte ist the main target for CDV and that astroglial infection may play an important role in the mechanism of demyelination.Supported by the Swiss National Science Foundation (grant no. 3.956.87) and the Swiss Multiple Sclerosis Society |
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Keywords: | Canine distemper virus Astrocyte Immunocytochemistry Demyelination |
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