慢性心力衰竭患者肝功能损伤、肾功能不全发生率及其与心力衰竭严重程度的关系

目的:研究慢性心力衰竭(CHF)患者肝功能损伤及肾功能不全的发生率,探讨丙氨酸氨基转移酶(ALT)、肌酐(Cr)水平的变化及与心功能变化的关系。方法:收集288例CHF患者的临床资料,根据NYHA心功能分级将患者分为心功能Ⅰ、Ⅱ、Ⅲ、Ⅳ级组,计算各组肝功能损伤、肾功能不全发生率,探讨ALT、Cr水平的变化及其与心功能分级的关系。结果:CHF患者肝功能损伤、肾功能不全的发生率分别为42.0%、38.5%,并且随着心功能分级的升高,肝功能损伤、肾功能不全患病率也在升高;随着心功能的恶化,血清ALT、Cr浓度在升高,且4组间有统计学差异(P<0.05)。结论:CHF患者中肝功能损伤、肾功能不全相当普遍,随着NYHA心功能分级的升高,肝肾功能在恶化。

Relationship between prevalence of hepatic function and renal insufficiency and their severity degree in patients with congestive heart failure

Abstract： Objective To study the prevalence of hepatic function and renal insufficiency and to analyze the relation of ALT and Cr with heart function in patients with congestive heart failure(CHF). Methods The data of 288 patients with CHF were collected．Based on NYHA ,the patients with heart failure were divided intoⅠ、Ⅱ、Ⅲ、Ⅳcardiac functional grading group．The prevalence of hepatic function and renal insufficiency was determined ,and the relation of ALT and Cr with heart function was analyzed.Results The prevalence of hepatic function and renal insuffieieney respectively was 42.01％ and 38.54％．With the development of NYHA cardiac functional grading．The prevalence of hepatic function and renal insufficiency gradually increased(P<0．01)．As the cardic function worsened，Cr level gradually increased(P<0．05).Conclusion with the devlopment of NYHA cardiac functional grading，the prevalence of hepatic function and renal insufficiency increases.The results indicate that hepatic function and renal insuffiency is a common disease in CHF patients．