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天麻提取物的纯化工艺研究
引用本文:范震宇,吴 云,窦 霞,刘 涛,萧 伟. 天麻提取物的纯化工艺研究[J]. 世界科学技术-中医药现代化, 2011, 13(2): 353-358
作者姓名:范震宇  吴 云  窦 霞  刘 涛  萧 伟
作者单位:范震宇 (南京中医药大学药学院,南京,210046) ; 吴云 (江苏康缘药业股份有限公司,连云港,222001) ; 窦霞 (中药制药过程新技术国家重点实验室,连云港,222001) ; 刘涛 (江苏省企业院工工作站,连云港,222001) ; 萧伟 (江苏康缘药业股份有限公司,连云港,222001) ;
基金项目:科学技术部重大新药创制项目(2009ZX09313-032):创新中药中试放大研究技术平台,负责人:萧伟
摘    要:目的:研究并建立天麻提取物的纯化工艺。方法:采用大孔吸附树脂与醇溶液调pH沉淀法联用技术对天麻提取物进行纯化。结果:经过工艺优选后,天麻提取物的出膏率为2.33%,其中天麻素的含量为23.50%,天麻总苷的含量为33.52%。结论:该工艺较传统醇沉工艺大大提高提取物天麻素的含量,且工艺稳定、可靠。

关 键 词:天麻  提取物  天麻素  纯化
收稿时间:2010-10-14
修稿时间:2010-11-09

Study on Purification of Extraction from Gastrodia elata Bl
Fan Zhenyu,Wu Yun,Dou Xi,Liu Tao and Xiao Wei. Study on Purification of Extraction from Gastrodia elata Bl[J]. World Science and Technology—Modernization of Traditional Chinese Medicine and Materia Medica, 2011, 13(2): 353-358
Authors:Fan Zhenyu  Wu Yun  Dou Xi  Liu Tao  Xiao Wei
Affiliation:Pharmacy Department,Nanjing University of Traditional Chinese Medicine,Nan Jing 210046,China;Jangsu Kanion Pharmaceutical Co.Ltd.,Lianyungang 222001,China;State Key Laboratory of Pharmaceutical Process New-tech for Chinese Medicine,Lianyungang 222001,China;Enterprises Academician Workstations in Jiangsu Province,Lianyungang 222001,China
Abstract:This study aimed to establish the best purification technique for the extraction from Gastrodia elata Bl.The condition of purification was confirmed through macroporous resin,alcohol-sedimentation and sedimentation of different pH values.The results showed that the paste rate of extraction from Gastrodia elata Bl was 2.33%,the content of gastrodin and total saponins were 23.50% and 33.52%,respectively.It is concluded that this method is suitable for the purification of Gastrodia elata Bl extraction.Compared with traditional alcohol precipitation method,this process is simple with high transfer content of gastrodin and other main target components.This method is proved to be stable and reliable in the extraction from Gastrodia elata Bl.
Keywords:
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