不同年龄组亲属肾移植供体术后肾功能的观察

目的总结分析不同年龄组亲属肾移植供体术后早期肾功能的变化情况。方法回顾性分析我院2006年1月至2008年3月69例亲属肾移植供体术前、术后血肌酐(Cr)的临床资料。结果 69例捐赠者平均年龄45.3岁,≥60岁7例,50～59岁24例,30～49岁29例,<30岁9例。术前总体血肌酐平均值为(64±14)μmol/L。<30岁组:术前血肌酐为(63±11)μmol/L,术后第1天为(90±15)μmol/L,较术前增加;术后第10天为(82±12)μmol/L,较术后第1天减少,但术后第10天与第1天比较差异无统计学意义(P=0.136)。30～49岁组:术前血肌酐为(66±16)μmol/L,术后第1天为(100±22)μmol/L,较术前增加;术后第10天为(90±20)μmol/L,较术后第1天减少,术后第10天与第1天比较差异有统计学意义(P=0.0054)。50～59岁组:术前血肌酐为(63±12)μmol/L,术后第1天为(103±29)μmol/L,较术前增加;术后第10天为(87±19)μmol/L,较术后第1天减少,术后第10天与第1天比较差异有统计学意义(P=0.006)。≥60岁组术后第10天与第1天血肌酐比较差异无统计学意义。结论①活体肾移植供体术后血肌酐会出现明显增高,并随年龄增加,波动幅度逐渐增大;术后第10天即可缓慢下降,30～59岁捐赠者下降明显。②30～59岁捐赠者肾脏代偿能力优于60岁以上或30岁以下的捐赠者。

Early postoperative renal function changes in living-related kidney donors of different age groups

Objective To summarize the early postoperative renal function changes in living-related renal donors of different age groups.Methods The clinical data of 69 donors′ preoperative and postoperative serum creatinine(Cr) in our hospital from January 2006 to March 2008 were collected and analyzed retrospectively.Results Sixty-nine donors were at the average age of 45.3.Preoperative blood Cr overall average value was(64±14)μmol/L.In group below 30 years old,the preoperative Cr average value was(63±11)μmol/L,while an average of(90±15)μmol/L in the first day after surgery.The average value was(82±12)μmol/L in the 10th postoperative day.There was no clear statistical significance between the two days(P=0.136).In donors from 30 to 49 years old,the data were(66±16)μmol/L,(100±22)μmol/L,(90±20)μmol/L,respectively.In comparison,there appeared obvious statistical significance(P=0.0054).As for group of 50 to 59 years old,the data were(63±12)μmol/L,(103±29)μmol/L and(87±19)μmol/L respectively.There was evident statistical difference(P=0.006).Conclusion ①Serum creatinine after living renal transplantation surgery will be significantly increased,and with the age rising,the range of fluctuation increases gradually.But it can decline slowly in the 10th day after the surgery,obviously in those donors from 30 to 59 years old.②The kidney compensatory ability of donors at the age of 30 to 59 is superior to those above 60 or below 30 years old.