| 多种癌、癌旁与正常组织中BAG-1表达的组织芯片检测与分析 |
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| 引用本文： | 师建国,林雨冬,闫庆国,王文勇,王泊云,王文亮.多种癌、癌旁与正常组织中BAG-1表达的组织芯片检测与分析[J].西北国防医学杂志,2004,25(4):263-265,F003. |
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| 作者姓名： | 师建国 林雨冬 闫庆国 王文勇 王泊云 王文亮 |
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| 作者单位： | 1. 第四军医大学西京医院病理科,陕西,西安,710032
2. 解放军第95医院外科 |
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| 摘 要： | 目的 :检测凋亡相关基因BAG - 1在乳腺癌、胃癌、宫颈癌及其癌旁组织、正常组织中的表达 ,并讨论其意义。方法 :利用组织芯片采用免疫组化DAKOEnvision法检测乳腺癌、胃癌、宫颈癌及其癌旁组织、正常组织中BAG - 1的表达。结果 :组织芯片中BAG - 1在乳腺癌、胃癌、宫颈癌组织中的表达比其对应癌旁组织、正常乳腺组织中高 ,差异明显 (P <0 .0 5 )。结论 :BAG- 1在乳腺癌、胃癌、宫颈癌组织中表达高于癌旁组织和正常组织 ,提示BAG - 1表达可能与这些恶性肿瘤的发生有关。
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| 关 键 词： | 免疫组化 BAG-1 肿瘤 细胞凋亡 组织芯片 |
| 文章编号： | 1007-8622(2004)04-0263-05 |
| 修稿时间： | 2004年4月16日 |
Expression and significance of apoptosis related gene BAG-1 in several cancer by tissue microarray |
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| SHI Jian-guo ,LIN Yu-dong ,YAN Qing-guo ,et al..Expression and significance of apoptosis related gene BAG-1 in several cancer by tissue microarray[J].Medical Journal of National Defending Forces in Northwest China,2004,25(4):263-265,F003. |
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| Authors: | SHI Jian-guo LIN Yu-dong YAN Qing-guo |
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| Institution: | SHI Jian-guo 1,LIN Yu-dong 2,YAN Qing-guo 1,et al . |
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| Abstract: | Objective:To detect BAG-1 expressions in breast cancer, gastric cancer and cervical cancer by tissue microarray and to evaluate it's clinical significance. Methods: Tissue microarray of breast cancer,gastric cancer,cervical cancer and their benign tumor and normal tissues were analyzed by DAKO Envision system immunohistochemical staining for apoptosis related gene BAG-1 expression. Results: The positive rate of BAG-1 expression among breast cancer,gastric cancer and cervical cancer were higher than that in the benign tumor and normal tissues respectively,and significant difference were observed( P <0.05).Conclusion: There is an overexpression of BAG-1 in breast cancer,gastric cancer and cervical cancer,it suggests that apoptosis related gene BAG-1 may be related to these cancer. |
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| Keywords: | Immunohistochemistry BAG-1 Neoplasm Apoptosis Tissue microarray |
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