血脂改变与2型糖尿病血管并发症的关系

目的研究2型糖尿病和2型糖尿病合并血管并发症患者血脂水平的变化，探讨血脂异常在2型糖尿病血管并发症发生中的作用。方法测定50例2型精尿病无血管并发症患者，56例2型糖尿病伴血管并发症患者及53例正常对照者系列血脂、空腹血糖水平。结果①糖尿病组与对照组比较，血清甘油三酯(TG)、胆固醇(TC)、低密度脂蛋白(LDL)、载脂蛋白B(Apo-B100)显著升高(P＜0.05或0.01)，高密度脂蛋白(HDL)显著降低(P＜0.05或0.01)。②2型糖尿病伴血管并发症组与无血管并发症组比较，TG、TC、LDL、Apo-B100显著升高(P＜0.01)，HDL显著降低(P＜0.01)。③空腹血糖(FBS)与TG、TC、LDL、Apo-B100呈正相关(r=0.32、0.22、0.28、0.21，P＜0.05)，与HDL呈负相关(r=-0.26，P＜0.05)，与Apo-A1无相关性(r=0.076，P＞0.05)。结论空腹血糖水平与血脂异常程度相关，脂代谢障碍是2型糖尿病血管并发症的重要因素。

Relationship Between Diabetic Angiopathy and blood Lipid.

Objective To study the relationship between diabetic angiopathy and blood lipid, and study the role of blood lipid on diabetic angiophy. Methods The concentrations of TC, TG, lipoproteins apolipoproteins and fasting blood glucose were determined in 50 patients without angiopathy, 56 patients with angiopathy and 53 healthy subjects. Results TC, TG, LDL, Apo - B100 in two group were higher than those in healthy subjects ( P ＜ 0. 05 or 0. 01 ), HLD were lower than those in healthy subjucts( P ＜ 0. 05 or 0. 01 ). TC, TG,LDL, Apo - B100 in patients with angiopathy were higher than those in patients without angiopathy( P ＜ 0. 01 ), HLD were lower than those in patients without angiopathy( P ＜ 0. 01 ). FBS was positivaly correlated with TC, TG, LDL, Apo - B100, and nesgatival corrlated with HLD (r=0.22, 0.32, 0.28, 0.21, -0.26, P ＜0.05) in two group patients. Conclusion FBS was correlated with blood lipid. Obstruction of blood lipid metabolism was an important faiot of type - 2 diabetes mellitus with angiopathy.