当归抗高脂致家兔主动脉粥样硬化效果观察

目的：通过观察当归影响实验性高脂致家兔主动脉粥样硬化的效果，探讨当归抗动脉粥样硬化作用的机制。方法：取健康家兔随机分正常对照组(普通饲料喂养)；高脂组(高脂饲料喂养)和当归治疗组(高脂饲料加当归注射液)。喂养10周末处死动物，检测主动脉AS斑块面积，透射电镜观察主动脉超微结构的变化，并速将主动脉条置入不同乙酰胆碱(Ach)浓度中，用Griess反应法检浏一氧化氮(NO)含量。结果：当归可显减小粥样班块面积，抑制动脉壁泡沫细胞形成，并增加主动脉NO的生成含量。结论：当归可桔抗高指导致的动脉粥样硬化的形成，这种作用可能与它保护内皮细胞、减少泡沫细胞形成、影响NO生成有关。

Effect of Angelica on High Lipid Induced Atherosclerosis in Rabbits Aorta

To study the antiatherosclerosis effect of angelica and its mechanism. Methods: Healthy rabbits were divided randomly into normal control group (common forage), high lipid model group (high lipid forage) and angelica group (high lipid forage adding angelica injection). At the end of 10 th week, aorta were obtained from the rabbits. Aorta were prepared for measurement of plaque area, observation of aorta ultrastructure and detection of aorta NO production induced by Ach in Griess reaction. Results: Angelica could decrease the plaque area significantly, inhibit the formation of foam cell in artery and increase the release of NO in aorta. Conclusion: Angelica can inhibit atherogenesis, which maybe relate to its effects of protecting ECs, decreasing the formation of foam cell and influencing NO synthesis.