| 疟原虫抗原的免疫抑制效应分析 |
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| 引用本文： | 徐大为,程道新.疟原虫抗原的免疫抑制效应分析[J].承德医学院学报,1996,13(1):10-13. |
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| 作者姓名： | 徐大为 程道新 |
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| 作者单位： | 北京医科大学寄生虫学教研室 |
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| 摘 要： | 本文报道伯瓦疟原虫分离、提纯的四种抗原具免疫抑制效应。应用单克隆抗体免疫荧光试验检测结果，四种不同方法处理的疟原虫抗原可造成小鼠脾ＤＣ４Ｔ细胞和Ｂ细胞阳性百分数下降，ＣＤ８Ｔ细胞百分数明显升高。结果表明，四种抗原中具有免疫抑制性抗原组分，通过诱导、激活ＣＤ８Ｔ细胞而对宿主的免疫应答起下调作用。四种抗原中，抗原提纯度高，免疫抑制效应随之增强。
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| 关 键 词： | 伯氏疟原虫 疟原虫 抗原 免疫抑制 |
ANALYSIS OF IMMUNOSUPPERSSIVE EFFECT OF DIFFERENT ANTIGENS IN PLASMODIUM BERGHEI |
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| xu Dawei,Cheng Daoxin.ANALYSIS OF IMMUNOSUPPERSSIVE EFFECT OF DIFFERENT ANTIGENS IN PLASMODIUM BERGHEI[J].Journal of Chengde Medical College,1996,13(1):10-13. |
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| Authors: | xu Dawei Cheng Daoxin |
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| Institution: | xu Dawei;Cheng Daoxin Department of parasitology |
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| Abstract: | The four antigens isolated and purificated from Plasmodium bergheihad the effect of immunosuppression. With monoclonal antibody immunofluorscenceassay,the positivity percentage of B and CD4T-cell were decreased in the mice treatedwith these antigens.The positivity percentage af CD8T-cell,however,was signiticantlyincreasrd.The resuIts show that the composition having immunosuppressive antigen is inthese antigens and it inhibits the immune responses of host by inducing and activatingCD8 T-cell. |
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| Keywords: | Plasmodium berghei immunosuppression monoclonal antibodyimmunofluorescence assay Department of Parasitology Beijing Medical University |
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