男性饮酒及体质指数与良性前列腺增生关系

目的 探讨饮酒、体质指数与良性前列腺增生(BPH)的关系。方法 采用病例对照研究方法。病例为2004~2006年临床诊断为良性前列腺增生、施行手术治疗、术后病理证实为BPH的患者,年龄为56~88岁。对照为同期住院的非前列腺增生患者,年龄与病例相同。以1:1匹配。病例与对照各334例,采用自行设计的调查表对研究对象进行调查。内容包括一般情况、身体测量、生活方式(吸烟、饮食、饮酒情况等)、既往史以及前列腺疾病的家族史等。采用Logistic回归模型计算OR值和95%CI。结果 病例组脑力劳动者所占的比例高于对照组,但其所从事的职业性活动却低于对照组,二者差异有统计学意义(χ²=4.446,P<0.05)。与不饮酒者比较,每天酒精摄入量为31~45 g者其OR=0.652,95%CI=0.484~0.878;洒精摄入量为46~60 g/d者其OR=0.533,95%CI=0.307~0.924。但重度饮酒者这种相关性减弱,酒精摄入量>60 g/d者与不饮酒者比,OR值增大,OR=0.623,95%CI=0.438~0.886。结论 酒精摄入量与BPH危险性间呈U型关系,而饮酒的年限、体重指数与BPH发病无关系。适量饮酒(酒精摄入量≤60 g/d)可能是BPH发病的保护因素。

Association of alcohol consumption, body mass index with benign prostatic hyperplasia of men

Objective To investigate the association between alcohol consumption,body mass index(BMI)and clinical benign prostatic hypeplasia(BPH).Methods A hospital-based case-control study was conducted,including men who were surgically treated BPH between 2004 and 2006(n=334),56～88 years old;non cases(controls)were men who admitted to the same hospital with different diseases which not related with prostatic conditions.Case and control were taken for 1:1 pair-matching.All subjects were interviewed during their hospital stay,using a structured interviewer-administered question-naire that included information on socio-demographic characteristics,lifest yle habits(smoking,dietary and alcohol consumption,etc.),detailed medical history and family history of BPH in first-degree relatives.Odds ratios(ORs)and corresponding 95% confidence intervals were estimated using conditional Logistic regression models including terms for age,occupation,education,alcohol consumption,BMI and the family history of BPH.Results The proportion with mental labors was higher than men in the case group and had fewer professional activities,significant difference was noticed in the two groups(χ²=4.446,P<0.05).After adjusted for age,BMI,alcohol consumption was inversely related with BPH(31～45 g/d vs.0:OR=0.652,95%CI:0.484～0.878,P<0.05;46～60g/d vs.0:OR=0.533,95%CI:0.307～0.924,P<0.05).Although the relation was attenuated athigh intake(>60 g/d vs.0:OR=0.623195%CI:0.438～0.886,P<0.05).Conclusion It should be noted that in this study a U-shaped association between alcohol consumption and the risk of BPH was found.No trend in risk emerged in relation to the duration of drinking,BMI and BPH.Moderate alcohol consumption may be of benefit to BPH.