Neuropeptide substance P improves water maze performance in aged rats |
| |
| Authors: | R. U. Hasenöhrl J. P. Huston T. Schuurman |
| |
| Affiliation: | (1) Institute of Physiological Psychology, University of Düsseldorf, Universitätsstrasse 1, D-4000 Düsseldorf, Federal Republic of Germany;(2) Department of Neurobiology, Troponwerke GMBH & CO.KG, Berliner Strasse 156, D-5000 Köln, Federal Republic of Germany |
| |
| Abstract: | The effects of the peripherally administered neuropeptide substance P (SP) on spatial learning capacities were investigated in 27-month-old rats using a water-maze task. Old rats were injected intraperitoneally once daily for 6 days with 50 or 250 µg/kg SP or vehicle 30 min prior to acquisition trials. Improvement in maze performance was observed following injections of 250 µg/kg SP only. Furthermore, vehicle-treated old rats showed significantly poorer acquisition rates than vehicle-treated 12-week-old rats. Thus, the improvement in performance after the 250 µg/kg dose of SP can be interpreted in terms of a compensation of performance deficit in the old rats. |
| |
| Keywords: | Substance P Aging Spatial learning Water maze Old rat |
| 本文献已被 SpringerLink 等数据库收录！ |
|
