S cases have increased levels of interleukin-6 in cerebrospinal fluid |
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| Authors: | Å Vege TO Rognum H Scott AO Aasen OD Saugstad |
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| Institution: | Institute of Forensic Medicine, Rikshospitalet, Oslo, Norway;Institute of Pathology, Rikshospitalet, Oslo, Norway;Institute of Surgical Research, Rikshospitalet, Oslo, Norway;Department of Pediatric Research, Rikshospitalet, Oslo, Norway |
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| Abstract: | Cerebrospinal fluid (CSF) from 20 infants who died of sudden infant death syndrome (SIDS), 7 cases of infectious death and 5 cases of violent death were examined with respect to concentrations of interleukin-6 (IL-6). The measurements were performed by ELISA. IL-6 levels in SIDS were significantly lower than in infectious death (p < 0.02), but significantly higher than in violent death (p < 0.02). Since IL-6 plays an important role in immune responses and may induce fever, the findings may suggest that immune activation plays a role in SIDS. The presence of cytokines in the central nervous system (CNS) may cause respiratory depression, especially in vulnerable infants. |
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| Keywords: | Cerebrospinal fluid interleukin-6 mucosal immune stimulation SIDS |
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