氧化／抗氧化失衡在COPD稳定期慢性肺损伤的机制研究

目的探讨稳定期不同级别COPD患者血清中氧化／抗氧化因子及细胞炎症因子水平与肺功能主要指标的关系。方法选取COPD稳定期患者80例，检测各患者肺功能与血清中反应性氧核素（ROS）、超氧化物歧化酶（SOD）及细胞炎症因子水平，观测各组的差异并分析其相关性。结果FEV1、FVC、FEV1／FVC、SOD、ROS、TNF．d、IL-8、GM—CSF水平在不同组别中存在差异（P〈0．05），ROS、TNF-a、IL-8、GM—CSF水平与FEV1，FVC、FEV1／FVC存在着明显的负相关（P〈0．05），SOD与其存在明显正相关（P〈0．05）。结论COPD细胞炎症因子的持续升高及氧化加重可能是引起稳定期COPD肺组织慢性损伤、功能降低的重要机制。

Mechanism research on oxidation/anti-oxidation imbalance in patients with chronic lung scathing of chronic obstructive pulmonary disease at stable stage

Objective To explore the relationship of serum oxidation/anti-oxidation and the level of inflammatory eytokines to pulmonary functions in patients with COPD at stable stage. Methods 80 COPD patients at stable stage were divided into I degree, Ⅱ degree, m degree and Ⅳ degree Group based on GOLD grading standard. The pulmonary function and the levels of ROS, SOD and inflammatory cytokines in serum were detected and analyzed. Results The levels of FEV1 , FVC, FEV1/FVC, SOD, ROS, TNF-a, IL-8 and GM-CSF were significantly different in the different degrees （ P 〈0. 05 ）. The levels of ROS, TNF-A, IL-8, and GM-CSF were negatively correlated with that of FEV1 and FVC, but SOD were positively correlated with lung function. Conclusion The continuous increase of inflammatory cytokines and the exacerbation of oxidation may be the causes of chronic damage in pulmonary tissues and decrease of pul- monary function in COPD patients at stable phase.