In vitro evaluation of E-4695, a new fluoro-naphthyridine

Compound E-4695, a C-7 azetidinyl fluoro-naphthyridine, was compared to six structurally related quinolones and was generally two- to four-fold more active than ciprofloxacin. E-4695 was particularly active againstStaphylococcus aureus (MIC90 0.06 mg/l),Staphylococcus haemolyticus (MIC90 0.5 mg/l),Klebsiella spp. (MIC900.015 mg/l),Serratia marcescens (MIC90 0.06 mg/l),Acinetobacter spp. (MIC900.015 mg/l),Pseudomonas aeruginosa (MIC90 0.5 mg/l),Xanthomonas maltophilia (MIC90 0.5 mg/l), andNeisseria gonorrhoeae (MIC900.001 mg/l). This new quinolone-like drug requires further investigations to confirm these promising in vitro findings.